Impaired dendritic growth and positioning of cortical pyramidal neurons by activation of aryl hydrocarbon receptor signaling in the developing mouse

• Published in: PloS one Vol. 12; no. 8; p. e0183497
• Main Authors: Kimura, Eiki, Kubo, Ken-Ichiro, Endo, Toshihiro, Ling, Wenting, Nakajima, Kazunori, Kakeyama, Masaki, Tohyama, Chiharu
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 18.08.2017; Public Library of Science (PLoS)
• Subjects: Abnormalities; Activation analysis; Animals; Aromatic compounds; Biology; Biology and Life Sciences; Brain; Brain research; Cell migration; Cerebral cortex; Cerebrum; Cortex (somatosensory); Dendrites; Dendritic branching; Dendritic cells; Dendritic structure; Dioxins; Electroporation; Embryos; Environmental health; Genetic aspects; Health sciences; Helix-loop-helix proteins; Helix-loop-helix proteins (basic); Hydrocarbons; Insulin-like growth factors; Integrative medicine; Invertebrates; Laboratories; Laboratory animals; Laboratory tests; Ligands; Mammals; Medicine and Health Sciences; Mice; Mice, Inbred C57BL; Morphology; Nervous system; Neurons; Perinatal exposure; Physiological aspects; Pollutants; Preventive medicine; Pyramidal cells; Pyramidal Cells - metabolism; Receptors, Aryl Hydrocarbon - metabolism; Research and Analysis Methods; Rodents; Signal Transduction; Somatosensory cortex; Stems; Transcription activation; Transcription factors; Vertebrates; Japan

The basic helix-loop-helix (bHLH) transcription factors exert multiple functions in mammalian cerebral cortex development. The aryl hydrocarbon receptor (AhR), a member of the bHLH-Per-Arnt-Sim subfamily, is a ligand-activated transcription factor reported to regulate nervous system development in b...