Identification of HLA-DRB1 association to adalimumab immunogenicity

• Published in: PloS one Vol. 13; no. 4; p. e0195325
• Main Authors: Liu, Mohan, Degner, Jacob, Davis, Justin Wade, Idler, Kenneth B., Nader, Ahmed, Mostafa, Nael M., Waring, Jeffrey F.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 03.04.2018; Public Library of Science (PLoS)
• Subjects: Adalimumab; Adalimumab - immunology; Adalimumab - therapeutic use; Alleles; Analysis; Anti-Inflammatory Agents - immunology; Anti-Inflammatory Agents - therapeutic use; Antibodies; Antigens; Antirheumatic Agents - immunology; Antirheumatic Agents - therapeutic use; Arthritis; Arthritis, Rheumatoid - blood; Arthritis, Rheumatoid - drug therapy; Arthritis, Rheumatoid - genetics; Arthritis, Rheumatoid - immunology; Autoantibodies; Biology and Life Sciences; Clinical trials; Dosage and administration; Drb1 protein; Drug dosages; Drug therapy; Genomics; Health aspects; Hidradenitis Suppurativa - blood; Hidradenitis Suppurativa - drug therapy; Hidradenitis Suppurativa - genetics; Hidradenitis Suppurativa - immunology; Histocompatibility antigen HLA; Histocompatibility Testing; HLA antigens; HLA-DQ beta-Chains - blood; HLA-DQ beta-Chains - genetics; HLA-DRB1 Chains - genetics; Humans; Immunogenicity; Immunoglobulins; Immunotherapy; Infliximab; Interferon; Medical research; Medicine and Health Sciences; Monoclonal antibodies; Multiple sclerosis; Patients; Pharmacogenomic Variants; Philosophy of science; Physiological aspects; Research and Analysis Methods; Rheumatoid arthritis; Sequence Analysis; Skin diseases; Tissue typing; TNF inhibitors; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Values; United States > US; North Chicago Illinois

Anti-drug antibody formation occurs with most biological agents across disease states, but the mechanism by which they are formed is unknown. The formation of anti-drug antibodies to adalimumab (AAA) may decrease its therapeutic effects in some patients. HLA alleles have been reported to be associat...