Enhanced IL-6/IL-6R Signaling Promotes Growth and Malignant Properties in EBV-Infected Premalignant and Cancerous Nasopharyngeal Epithelial Cells

• Published in: PloS one Vol. 8; no. 5; p. e62284
• Main Authors: Zhang, Guitao, Tsang, Chi Man, Deng, Wen, Yip, Yim Ling, Lui, Vivian Wai-Yan, Wong, Sze Chuen Cesar, Cheung, Annie Lai-Man, Hau, Pok Man, Zeng, Musheng, Lung, Maria Li, Chen, Honglin, Lo, Kwok Wai, Takada, Kenzo, Tsao, Sai Wah
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.05.2013; Public Library of Science (PLoS)
• Subjects: Activation; Animals; Biology; Cancer; Care and treatment; Cell Line, Tumor; Cell Proliferation; Cytokines; Development and progression; Epithelial cells; Epithelial Cells - physiology; Epstein-Barr virus; Epstein-Barr Virus Infections - immunology; Epstein-Barr Virus Infections - metabolism; Etiology; Gene Expression; Gene Expression Regulation, Neoplastic; Health aspects; Herpesvirus 4, Human - immunology; Humans; Infections; Inflammation; Interleukin 6; Interleukin 6 receptors; Interleukin-6 - genetics; Interleukin-6 - metabolism; Interleukins; Invasiveness; Kinases; Laboratories; Male; Medical research; Medicine; Mice; Mice, Nude; Nasopharyngeal cancer; Nasopharyngeal carcinoma; Nasopharyngeal Neoplasms - metabolism; Nasopharyngeal Neoplasms - pathology; Nasopharyngeal Neoplasms - virology; Neoplasm Transplantation; Pathogenesis; Precancerous Conditions - metabolism; Precancerous Conditions - pathology; Precancerous Conditions - virology; Properties (attributes); Receptors, Interleukin-6 - metabolism; Rodents; Signal Transduction; Signaling; Stat3 protein; STAT3 Transcription Factor - metabolism; Stromal cells; Throat cancer; Transcription; Transformation; Tumor Burden; Tumorigenicity; Tumors; Up-Regulation; Viral Matrix Proteins - genetics; Viral Matrix Proteins - metabolism; Virology; Viruses; China
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0062284

Nasopharyngeal carcinoma (NPC) is etiologically associated with Epstein-Barr virus (EBV) infection. However, the exact role of EBV in NPC pathogenesis remains elusive. Activation of signal transducer and activator of transcription 3 (STAT3) is common in human cancers including NPC and plays an impor...