Expression of microRNAs and Other Small RNAs in Prefrontal Cortex in Schizophrenia, Bipolar Disorder and Depressed Subjects

• Published in: PloS one Vol. 9; no. 1; p. e86469
• Main Authors: Smalheiser, Neil R., Lugli, Giovanni, Zhang, Hui, Rizavi, Hooriyah, Cook, Edwin H., Dwivedi, Yogesh
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 27.01.2014; Public Library of Science (PLoS)
• Subjects: Base Sequence; Biology; Biosynthesis; Bipolar disorder; Bipolar Disorder - genetics; Bipolar Disorder - metabolism; Brain research; Brodmann's area; Cohort Studies; Comparative analysis; Consortia; Depression - genetics; Depression - metabolism; Diagnostic systems; Enrichment; Epigenetics; Female; Gene expression; Gene Expression Regulation - genetics; Gene regulation; Gene sequencing; Genes; Genetic aspects; Genetic transcription; Genomes; High-Throughput Nucleotide Sequencing; Humans; Male; Medical research; Medicine; Medicine, Experimental; Mental depression; Mental disorders; MicroRNA; MicroRNAs; MicroRNAs - metabolism; miRNA; Molecular Sequence Data; Neuropathology; Neurophysiology; Non-coding RNA; Nucleotide sequence; Polymerase chain reaction; Post-transcription; Prefrontal cortex; Prefrontal Cortex - metabolism; Psychiatry; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleic acid; RNA; Schizophrenia; Schizophrenia - genetics; Schizophrenia - metabolism; Sequence Analysis, DNA; Statistics, Nonparametric; Studies; Suicidal Ideation; Suicide; Synaptosomes; Synaptosomes - metabolism; United States > US; Illinois; Chicago Illinois

Because of the role played by miRNAs in post-transcriptional regulation of an array of genes, their impact in neuropsychiatric disease pathophysiology has increasingly been evident. In the present study, we assessed microRNA expression in prefrontal cortex (Brodmann area 10) of a well-characterized...