Chitosan as a Biomaterial: Influence of Degree of Deacetylation on Its Physiochemical, Material and Biological Properties

• Published in: PloS one Vol. 10; no. 8; p. e0135153
• Main Authors: Foster, Leslie John Ray, Ho, Sonia, Hook, James, Basuki, Monica, Marçal, Helder
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 25.08.2015; Public Library of Science (PLoS)
• Subjects: Acetylation; Animals; Apoptosis; Biocompatibility; Biocompatible Materials - chemistry; Biocompatible Materials - pharmacology; Biological products; Biological properties; Biomaterials; Biomedical materials; Biotechnology; Cell cycle; Cell Line; Cell proliferation; Cell Proliferation - drug effects; Chemical Phenomena; Chitin; Chitin - chemistry; Chitosan; Chitosan - chemistry; Chitosan - pharmacology; Crustaceans; Crystallization; Deacetylation; Elongation; Feasibility studies; Genetic aspects; Hydrophobic and Hydrophilic Interactions; Materials Testing; Mitochondria; NMR; Nuclear magnetic resonance; Olfactory Bulb - cytology; Olfactory Bulb - ultrastructure; Olfactory ensheathing cells; Physiochemistry; Polymers; Polyvinyl alcohol; Proton Magnetic Resonance Spectroscopy; Regeneration; Solvents; Surface Properties; Surface roughness; X-Ray Diffraction; United States; Sydney New South Wales Australia; Australia; United States > US

Chitosan is a biomaterial with a range of current and potential biomedical applications. Manipulation of chitosan degree of deacetylation (DDA) to achieve specific properties appears feasible, but studies investigating its influence on properties are often contradictory. With a view to the potential...