VEGF may contribute to macrophage recruitment and M2 polarization in the decidua

• Published in: PloS one Vol. 13; no. 1; p. e0191040
• Main Authors: Wheeler, Karen C., Jena, Manoj K., Pradhan, Bhola S., Nayak, Neha, Das, Subhendu, Hsu, Chaur-Dong, Wheeler, David S., Chen, Kang, Nayak, Nihar R.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 11.01.2018; Public Library of Science (PLoS)
• Subjects: Adult; Angiogenesis; Biology and Life Sciences; Cell culture; Cell Line; Cell Polarity; Cellular signal transduction; Conditioning; Cytokines; Decidua; Decidua - cytology; Endometrium; Endothelial cells; Female; Genotype & phenotype; Growth factors; Gynecology; Health aspects; Human subjects; Humans; Hypoxia; Immunohistochemistry; Leukocyte migration; Localization; Macrophages; Macrophages - cytology; Markers; Medicine and Health Sciences; Monocytes; Nitric oxide; Obstetrics; Polarity; Polarization; Pre-eclampsia; Preeclampsia; Pregnancy; Real-Time Polymerase Chain Reaction; Signaling; Stromal cells; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - physiology

It is increasingly evident that cytokines and growth factors produced in the decidua play a pivotal role in the regulation of the local immune microenvironment and the establishment of pregnancy. One of the major growth factors produced in the decidua is vascular endothelial growth factor (VEGF), wh...