Analysis of the outer membrane proteome and secretome of Bacteroides fragilis reveals a multiplicity of secretion mechanisms

• Published in: PloS one Vol. 10; no. 2; p. e0117732
• Main Authors: Wilson, Marlena M, Anderson, D Eric, Bernstein, Harris D
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 06.02.2015; Public Library of Science (PLoS)
• Subjects: Analysis; Bacterial Outer Membrane Proteins - biosynthesis; Bacterial Outer Membrane Proteins - genetics; Bacterial Secretion Systems - physiology; Bacteroides; Bacteroides fragilis; Bacteroides fragilis - genetics; Bacteroides fragilis - metabolism; Bacteroidetes; Biochemistry; Biotinylation; Blood lipids; Cell surface; Colonization; Diabetes; E coli; Escherichia coli; Genes; Genomes; Gram-negative bacteria; Humans; Intestinal microflora; Kidney diseases; Lipoproteins; Metabolism; Microbiomes; Molecular chains; Nutrient uptake; Opportunist infection; Pathogenicity; Pathogens; Polypeptides; Proteases; Protein composition; Proteins; Proteobacteria; Proteome - biosynthesis; Proteome - genetics; Proteomics; Secretion; Secretome; Substrates; United States > US

Bacteroides fragilis is a widely distributed member of the human gut microbiome and an opportunistic pathogen. Cell surface molecules produced by this organism likely play important roles in colonization, communication with other microbes, and pathogenicity, but the protein composition of the outer...