Host Adaptation and the Alteration of Viral Properties of the First Influenza A/H1N1pdm09 Virus Isolated in Japan
A/Narita/1/2009 (A/N) was the first H1N1 virus from the 2009 pandemic (H1pdm) to be isolated in Japan. To better understand and predict the possible development of this virus strain, the effect of passaging A/N was investigated in Madin-Darby canine kidney cells, chicken eggs and mice. A/N that had...
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| Published in | PloS one Vol. 10; no. 6; p. e0130208 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
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United States
Public Library of Science
16.06.2015
Public Library of Science (PLoS) |
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| Abstract | A/Narita/1/2009 (A/N) was the first H1N1 virus from the 2009 pandemic (H1pdm) to be isolated in Japan. To better understand and predict the possible development of this virus strain, the effect of passaging A/N was investigated in Madin-Darby canine kidney cells, chicken eggs and mice. A/N that had been continuously passaged in cells, eggs, or mice obtained the ability to grow efficiently in each host. Moreover, A/N grown in mice had both a high level of pathogenicity in mice and an increased growth rate in cells and eggs. Changes in growth and pathogenicity were accompanied by amino acid substitutions in viral hemagglutinin (HA) and PB2. In addition, the adapted viruses exhibited a reduced ability to react with ferret antisera against A/N. In conclusion, prolonged passaging allowed influenza A/N to adapt to different hosts, as indicated by a high increase in proliferative capacity that was accompanied by an antigenic alteration leading to amino acid substitutions. |
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| AbstractList | A/Narita/1/2009 (A/N) was the first H1N1 virus from the 2009 pandemic (H1pdm) to be isolated in Japan. To better understand and predict the possible development of this virus strain, the effect of passaging A/N was investigated in Madin-Darby canine kidney cells, chicken eggs and mice. A/N that had been continuously passaged in cells, eggs, or mice obtained the ability to grow efficiently in each host. Moreover, A/N grown in mice had both a high level of pathogenicity in mice and an increased growth rate in cells and eggs. Changes in growth and pathogenicity were accompanied by amino acid substitutions in viral hemagglutinin (HA) and PB2. In addition, the adapted viruses exhibited a reduced ability to react with ferret antisera against A/N. In conclusion, prolonged passaging allowed influenza A/N to adapt to different hosts, as indicated by a high increase in proliferative capacity that was accompanied by an antigenic alteration leading to amino acid substitutions. |
| Audience | Academic |
| Author | Odagiri, Takato Shirakura, Masayuki Asanuma, Hideki Obuchi, Masatsugu Nobusawa, Eri Hasegawa, Hideki Ujike, Makoto Ainai, Akira Tashiro, Masato |
| AuthorAffiliation | University of Geneva, SWITZERLAND 3 Department of Veterinary Medicine, Nippon Veterinary and Life Science University, Kyonancho 1-7-1, Musashino-shi, Tokyo, 180–8602, Japan 2 Department of Pathology, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo, 162–8640, Japan 1 Influenza Virus Research Center, National Institute of Infectious Diseases, Gakuen 4-7-1, Musashi-Murayama-shi, Tokyo, 208–0011, Japan |
| AuthorAffiliation_xml | – name: 3 Department of Veterinary Medicine, Nippon Veterinary and Life Science University, Kyonancho 1-7-1, Musashino-shi, Tokyo, 180–8602, Japan – name: 2 Department of Pathology, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo, 162–8640, Japan – name: 1 Influenza Virus Research Center, National Institute of Infectious Diseases, Gakuen 4-7-1, Musashi-Murayama-shi, Tokyo, 208–0011, Japan – name: University of Geneva, SWITZERLAND |
| Author_xml | – sequence: 1 givenname: Akira surname: Ainai fullname: Ainai, Akira – sequence: 2 givenname: Hideki surname: Hasegawa fullname: Hasegawa, Hideki – sequence: 3 givenname: Masatsugu surname: Obuchi fullname: Obuchi, Masatsugu – sequence: 4 givenname: Takato surname: Odagiri fullname: Odagiri, Takato – sequence: 5 givenname: Makoto surname: Ujike fullname: Ujike, Makoto – sequence: 6 givenname: Masayuki surname: Shirakura fullname: Shirakura, Masayuki – sequence: 7 givenname: Eri surname: Nobusawa fullname: Nobusawa, Eri – sequence: 8 givenname: Masato surname: Tashiro fullname: Tashiro, Masato – sequence: 9 givenname: Hideki surname: Asanuma fullname: Asanuma, Hideki |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26079133$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_vaccine_2019_07_032 crossref_primary_10_1016_j_heliyon_2018_e01113 crossref_primary_10_1016_j_tim_2020_06_005 crossref_primary_10_1371_journal_pone_0245244 crossref_primary_10_1371_journal_pone_0173008 crossref_primary_10_1134_S0026893318040052 crossref_primary_10_1093_intimm_dxad013 crossref_primary_10_1016_j_vaccine_2015_09_072 crossref_primary_10_1128_JVI_01073_16 crossref_primary_10_3390_v13091733 crossref_primary_10_1039_C8RA01690A crossref_primary_10_1089_dna_2019_5324 |
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| Copyright | COPYRIGHT 2015 Public Library of Science 2015 Ainai et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2015 Ainai et al 2015 Ainai et al |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 Competing Interests: The authors have declared that no competing interests exist. Conceived and designed the experiments: HA AA. Performed the experiments: MO MS. Analyzed the data: MU. Contributed reagents/materials/analysis tools: HA MT. Wrote the paper: HA. Management of some experiments: HH TO EN MT. |
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| SubjectTerms | Acids Adaptation, Physiological Amino Acid Substitution Amino acids Analysis Animals Antigens Antisera Chickens Dogs Eggs Female Ferrets - virology Growth rate Hemagglutinins Host-Pathogen Interactions Influenza Influenza A Influenza A Virus, H1N1 Subtype - genetics Influenza A Virus, H1N1 Subtype - immunology Influenza A Virus, H1N1 Subtype - physiology Japan Kinetics Madin Darby Canine Kidney Cells Mice Ovum - virology Pandemics Pathogenicity Pathogens Poultry Swine flu Vaccines Viruses |
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| Title | Host Adaptation and the Alteration of Viral Properties of the First Influenza A/H1N1pdm09 Virus Isolated in Japan |
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