Ketamine Decreases Resting State Functional Network Connectivity in Healthy Subjects: Implications for Antidepressant Drug Action - Scheidegger, Milan; Walter, Martin; Lehmann, Mick; Metzger, Coraline; Grimm, Simone; Boeker, Heinz; Boesiger, Peter; Henning, Anke; Seifritz, Erich (PloS one, 2012)
Keywords: Adult; Affective disorders; Antidepressants; Antidepressive Agents - pharmacology; Biology; Biomedical engineering; Brain; Brain Mapping; Brain research; Clinical trials; Cognitive ability; Cortex (cingulate); Cortex (temporal); Cross-Over Studies; Data processing; Depression (Mood disorder); Depressive Disorder, Major - drug therapy; Depressive Disorder, Major - pathology; Dosage and administration; Double-Blind Method; Drug therapy; Emotional disorders; Engineering; Female; Functional magnetic resonance imaging; Functional plasticity; Glutamatergic transmission; Glutamic acid receptors (ionotropic); Gyrus Cinguli - anatomy & histology; Gyrus Cinguli - drug effects; Gyrus Cinguli - physiology; Humans; Information processing; Injections, Intravenous; Intervention; Intravenous administration; Ketamine; Ketamine - pharmacology; Laboratories; Magnetic resonance; Magnetic Resonance Imaging; Male; Medical imaging; Medicine; Mental depression; Middle Aged; N-Methyl-D-aspartic acid receptors; Neural networks; Neural Pathways - anatomy & histology; Neural Pathways - drug effects; Neural Pathways - physiology; Neurobiology; Neuroimaging; Neurophysiology; Neurosciences; NMR; Nuclear magnetic resonance; Physiology; Placebos; Prefrontal cortex; Prefrontal Cortex - anatomy & histology; Prefrontal Cortex - drug effects; Prefrontal Cortex - physiology; Psychiatry; Septal Nuclei - anatomy & histology; Septal Nuclei - drug effects; Septal Nuclei - physiology; Signaling; Studies; Temporal lobe; Switzerland; Germany