The TNF-family cytokine TL1A inhibits proliferation of human activated B cells

• Published in: PloS one Vol. 8; no. 4; p. e60136
• Main Authors: Cavallini, Chiara, Lovato, Ornella, Bertolaso, Anna, Pacelli, Luciano, Zoratti, Elisa, Zanolin, Elisabetta, Krampera, Mauro, Zamò, Alberto, Tecchio, Cristina, Cassatella, Marco A, Pizzolo, Giovanni, Scupoli, Maria T
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 02.04.2013; Public Library of Science (PLoS)
• Subjects: Adaptive immunity; Antibodies; Antigens, CD - metabolism; Autoimmune diseases; B cells; B-Lymphocytes - drug effects; B-Lymphocytes - immunology; B-Lymphocytes - metabolism; Biology; Blood & organ donations; Cancer; Cell growth; Cell proliferation; Cell Proliferation - drug effects; Cell survival; Cell Survival - drug effects; Cytokines; Dendritic cells; Disease; Ethics; Gene expression; Genetic aspects; Health aspects; Hematology; Homeostasis; Humans; Immune response; Immune system; Immunofluorescence; Immunoglobulin M; Immunophenotyping; Inflammation; Interleukin 2; Kinases; Laboratories; Ligands; Lymphocyte Activation - drug effects; Lymphocyte Activation - immunology; Lymphocytes; Lymphocytes B; Lymphocytes T; Medical research; Medicine; Natural killer cells; Palatine Tonsil - immunology; Palatine Tonsil - metabolism; Pathology; Receptors, Tumor Necrosis Factor, Member 25 - metabolism; Rheumatoid arthritis; Spleen; Studies; T cell receptors; T cells; Tonsil; Tumor necrosis factor; Tumor Necrosis Factor Ligand Superfamily Member 15 - pharmacology; Tumor necrosis factor receptors; Italy

Death receptor (DR3) 3 is a member of the TNFR superfamily. Its ligand is TNF-like ligand 1A (TL1A), a member of the TNF superfamily. TL1A/DR3 interactions have been reported to modulate the functions of T cells, NK, and NKT cells and play a crucial role in driving inflammatory processes in several...