High Throughput Kinomic Profiling of Human Clear Cell Renal Cell Carcinoma Identifies Kinase Activity Dependent Molecular Subtypes

• Published in: PloS one Vol. 10; no. 9; p. e0139267
• Main Authors: Anderson, Joshua C., Willey, Christopher D., Mehta, Amitkumar, Welaya, Karim, Chen, Dongquan, Duarte, Christine W., Ghatalia, Pooja, Arafat, Waleed, Madan, Ankit, Sudarshan, Sunil, Naik, Gurudatta, Grizzle, William E., Choueiri, Toni K., Sonpavde, Guru
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 25.09.2015; Public Library of Science (PLoS)
• Subjects: Analysis; Anderson, Christopher; Authorship; Brain cancer; Cancer therapies; Carcinoma, Renal Cell - genetics; Carcinoma, Renal Cell - pathology; Care and treatment; Classification; Clear cell-type renal cell carcinoma; Cluster Analysis; Clustering; Diagnosis; Disease Progression; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genetic aspects; Health aspects; Hematology; Human subjects; Humans; Identification methods; Immune response; Immune system; Kidney cancer; Kidney Neoplasms - genetics; Kidney Neoplasms - pathology; Kidneys; Kinases; Lysates; Male; Medical research; Middle Aged; Mutation; Oncology; Patient outcomes; Patients; Phosphotransferases; Powder injection molding; Privacy; Protein Kinases - genetics; Protein Kinases - metabolism; Renal cell carcinoma; Ribosomal protein S6 kinase; Substrates; Target recognition; Therapeutic applications; Translation initiation; Treatment Outcome; Tumors; Vascular endothelial growth factor; United States; United Kingdom > UK; United States > US; Maine; Egypt; England; Alabama; Alexandria Egypt

Despite the widespread use of kinase-targeted agents in clear cell renal cell carcinoma (CC-RCC), comprehensive kinase activity evaluation (kinomic profiling) of these tumors is lacking. Thus, kinomic profiling of CC-RCC may assist in devising a classification system associated with clinical outcome...