The Physiological Period Length of the Human Circadian Clock In Vivo Is Directly Proportional to Period in Human Fibroblasts

• Published in: PloS one Vol. 5; no. 10; p. e13376
• Main Authors: Pagani, Lucia, Semenova, Ekaterina A., Moriggi, Ermanno, Revell, Victoria L., Hack, Lisa M., Lockley, Steven W., Arendt, Josephine, Skene, Debra J., Meier, Fides, Izakovic, Jan, Wirz-Justice, Anna, Cajochen, Christian, Sergeeva, Oksana J., Cheresiz, Sergei V., Danilenko, Konstantin V., Eckert, Anne, Brown, Steven A.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 15.10.2010; Public Library of Science (PLoS)
• Subjects: Aging; Biological clocks; Blindness; Brain; Cell Biology/Gene Expression; Circadian Clocks; Circadian rhythm; Circadian rhythms; Correlation analysis; Deprivation; Diurnal; Fibroblasts; Fibroblasts - cytology; Gene expression; Human behavior; Humans; Hypothalamus; Internal medicine; Laboratories; Light; Medicine; Melatonin; Mental health; Mutation; Neurobiology; Neuroscience/Behavioral Neuroscience; Neurosciences; Nuclei (cytology); Physiological aspects; Physiology; Physiology/Integrative Physiology; Properties (attributes); Rodents; Secretion; Toxicology; Urine; Switzerland

Diurnal behavior in humans is governed by the period length of a circadian clock in the suprachiasmatic nuclei of the brain hypothalamus. Nevertheless, the cell-intrinsic mechanism of this clock is present in most cells of the body. We have shown previously that for individuals of extreme chronotype...