The Influence of Physiological Aging and Atrophy on Brain Viscoelastic Properties in Humans

Physiological aging of the brain is accompanied by ubiquitous degeneration of neurons and oligodendrocytes. An alteration of the cellular matrix of an organ impacts its macroscopic viscoelastic properties which can be detected by magnetic resonance elastography (MRE)--to date the only method for mea...

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Published inPloS one Vol. 6; no. 9; p. e23451
Main Authors Sack, Ingolf, Streitberger, Kaspar-Josche, Krefting, Dagmar, Paul, Friedemann, Braun, Jürgen
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 12.09.2011
Public Library of Science (PLoS)
Subjects
Acoustics
Adolescent
Adult
Age
Age composition
Aged
Aging
Aging - pathology
Aging - physiology
Atrophy
Atrophy - diagnostic imaging
Atrophy - pathology
Atrophy - physiopathology
Boundary conditions
Brain
Brain - pathology
Brain - physiology
Brain - physiopathology
Brain research
Cross-Sectional Studies
Degeneration
Elasticity
Elasticity Imaging Techniques
Frontal lobe
Health informatics
Humans
Life span
Magnetic properties
Magnetic resonance
Male
Materials Science
Mechanical properties
Medicine
Middle Aged
Morphology
Musculoskeletal system
Neurodegeneration
Neurons
NMR
Nuclear magnetic resonance
Older people
Oligodendrocytes
Organ Size
Physics
Physiological aspects
Physiology
Polymers
Propagation
Quantitative analysis
Shrinkage
Trends
Viscoelasticity
Viscosity
Young Adult
Germany
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Abstract Physiological aging of the brain is accompanied by ubiquitous degeneration of neurons and oligodendrocytes. An alteration of the cellular matrix of an organ impacts its macroscopic viscoelastic properties which can be detected by magnetic resonance elastography (MRE)--to date the only method for measuring brain mechanical parameters without intervention. However, the wave patterns detected by MRE are affected by atrophic changes in brain geometry occurring in an individual's life span. Moreover, regional variability in MRE-detected age effects is expected corresponding to the regional variation in atrophy. Therefore, the sensitivity of brain MRE to brain volume and aging was investigated in 66 healthy volunteers aged 18-72. A linear decline in whole-brain elasticity was observed (-0.75%/year, R-square = 0.59, p<0.001); the rate is three times that determined by volume measurements (-0.23%/year, R-square = 0.4, p<0.001). The highest decline in elasticity (-0.92%/year, R-square = 0.43, p<0.001) was observed in a region of interest placed in the frontal lobe with minimal age-related shrinkage (-0.1%, R-square = 0.06, p = 0.043). Our results suggest that cerebral MRE can measure geometry-independent viscoelastic parameters related to intrinsic tissue structure and altered by age.
AbstractList Physiological aging of the brain is accompanied by ubiquitous degeneration of neurons and oligodendrocytes. An alteration of the cellular matrix of an organ impacts its macroscopic viscoelastic properties which can be detected by magnetic resonance elastography (MRE) - to date the only method for measuring brain mechanical parameters without intervention. However, the wave patterns detected by MRE are affected by atrophic changes in brain geometry occurring in an individual's life span. Moreover, regional variability in MRE-detected age effects is expected corresponding to the regional variation in atrophy. Therefore, the sensitivity of brain MRE to brain volume and aging was investigated in 66 healthy volunteers aged 18-72. A linear decline in whole-brain elasticity was observed (-0.75%/year, R-square = 0.59, p<0.001); the rate is three times that determined by volume measurements (-0.23%/year, R-square = 0.4, p<0.001). The highest decline in elasticity (-0.92%/year, R-square = 0.43, p<0.001) was observed in a region of interest placed in the frontal lobe with minimal age-related shrinkage (-0.1%, R-square = 0.06, p = 0.043). Our results suggest that cerebral MRE can measure geometry-independent viscoelastic parameters related to intrinsic tissue structure and altered by age.
Physiological aging of the brain is accompanied by ubiquitous degeneration of neurons and oligodendrocytes. An alteration of the cellular matrix of an organ impacts its macroscopic viscoelastic properties which can be detected by magnetic resonance elastography (MRE) – to date the only method for measuring brain mechanical parameters without intervention. However, the wave patterns detected by MRE are affected by atrophic changes in brain geometry occurring in an individual's life span. Moreover, regional variability in MRE-detected age effects is expected corresponding to the regional variation in atrophy. Therefore, the sensitivity of brain MRE to brain volume and aging was investigated in 66 healthy volunteers aged 18–72. A linear decline in whole-brain elasticity was observed (−0.75%/year, R-square = 0.59, p<0.001); the rate is three times that determined by volume measurements (−0.23%/year, R-square = 0.4, p<0.001). The highest decline in elasticity (−0.92%/year, R-square = 0.43, p<0.001) was observed in a region of interest placed in the frontal lobe with minimal age-related shrinkage (−0.1%, R-square = 0.06, p = 0.043). Our results suggest that cerebral MRE can measure geometry-independent viscoelastic parameters related to intrinsic tissue structure and altered by age.
Physiological aging of the brain is accompanied by ubiquitous degeneration of neurons and oligodendrocytes. An alteration of the cellular matrix of an organ impacts its macroscopic viscoelastic properties which can be detected by magnetic resonance elastography (MRE)--to date the only method for measuring brain mechanical parameters without intervention. However, the wave patterns detected by MRE are affected by atrophic changes in brain geometry occurring in an individual's life span. Moreover, regional variability in MRE-detected age effects is expected corresponding to the regional variation in atrophy. Therefore, the sensitivity of brain MRE to brain volume and aging was investigated in 66 healthy volunteers aged 18-72. A linear decline in whole-brain elasticity was observed (-0.75%/year, R-square = 0.59, p<0.001); the rate is three times that determined by volume measurements (-0.23%/year, R-square = 0.4, p<0.001). The highest decline in elasticity (-0.92%/year, R-square = 0.43, p<0.001) was observed in a region of interest placed in the frontal lobe with minimal age-related shrinkage (-0.1%, R-square = 0.06, p = 0.043). Our results suggest that cerebral MRE can measure geometry-independent viscoelastic parameters related to intrinsic tissue structure and altered by age.Physiological aging of the brain is accompanied by ubiquitous degeneration of neurons and oligodendrocytes. An alteration of the cellular matrix of an organ impacts its macroscopic viscoelastic properties which can be detected by magnetic resonance elastography (MRE)--to date the only method for measuring brain mechanical parameters without intervention. However, the wave patterns detected by MRE are affected by atrophic changes in brain geometry occurring in an individual's life span. Moreover, regional variability in MRE-detected age effects is expected corresponding to the regional variation in atrophy. Therefore, the sensitivity of brain MRE to brain volume and aging was investigated in 66 healthy volunteers aged 18-72. A linear decline in whole-brain elasticity was observed (-0.75%/year, R-square = 0.59, p<0.001); the rate is three times that determined by volume measurements (-0.23%/year, R-square = 0.4, p<0.001). The highest decline in elasticity (-0.92%/year, R-square = 0.43, p<0.001) was observed in a region of interest placed in the frontal lobe with minimal age-related shrinkage (-0.1%, R-square = 0.06, p = 0.043). Our results suggest that cerebral MRE can measure geometry-independent viscoelastic parameters related to intrinsic tissue structure and altered by age.
Audience Academic
Author Krefting, Dagmar
Paul, Friedemann
Streitberger, Kaspar-Josche
Sack, Ingolf
Braun, Jürgen
AuthorAffiliation 2 Institute of Medical Informatics, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
3 NeuroCure Clinical Research Center, Charité-Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany
University of California, San Francisco, United States of America
1 Department of Radiology, Charité-Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany
4 Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine, Berlin, Germany
AuthorAffiliation_xml – name: 3 NeuroCure Clinical Research Center, Charité-Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany
– name: University of California, San Francisco, United States of America
– name: 2 Institute of Medical Informatics, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
– name: 1 Department of Radiology, Charité-Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany
– name: 4 Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine, Berlin, Germany
Author_xml – sequence: 1
  givenname: Ingolf
  surname: Sack
  fullname: Sack, Ingolf
– sequence: 2
  givenname: Kaspar-Josche
  surname: Streitberger
  fullname: Streitberger, Kaspar-Josche
– sequence: 3
  givenname: Dagmar
  surname: Krefting
  fullname: Krefting, Dagmar
– sequence: 4
  givenname: Friedemann
  surname: Paul
  fullname: Paul, Friedemann
– sequence: 5
  givenname: Jürgen
  surname: Braun
  fullname: Braun, Jürgen
BackLink https://www.ncbi.nlm.nih.gov/pubmed/21931599$$D View this record in MEDLINE/PubMed
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ContentType Journal Article
Copyright COPYRIGHT 2011 Public Library of Science
2011 Sack et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Sack et al. 2011
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– notice: 2011 Sack et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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DocumentTitleAlternate Brain Viscoelasticity and Atrophy in Humans
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Conceived and designed the experiments: IS JB FP. Performed the experiments: IS K-JS. Analyzed the data: IS K-JS DK. Contributed reagents/materials/analysis tools: IS JB DK. Wrote the paper: IS FP JB.
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Snippet Physiological aging of the brain is accompanied by ubiquitous degeneration of neurons and oligodendrocytes. An alteration of the cellular matrix of an organ...
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StartPage e23451
SubjectTerms Acoustics
Adolescent
Adult
Age
Age composition
Aged
Aging
Aging - pathology
Aging - physiology
Atrophy
Atrophy - diagnostic imaging
Atrophy - pathology
Atrophy - physiopathology
Boundary conditions
Brain
Brain - pathology
Brain - physiology
Brain - physiopathology
Brain research
Cross-Sectional Studies
Degeneration
Elasticity
Elasticity Imaging Techniques
Frontal lobe
Health informatics
Humans
Life span
Magnetic properties
Magnetic resonance
Male
Materials Science
Mechanical properties
Medicine
Middle Aged
Morphology
Musculoskeletal system
Neurodegeneration
Neurons
NMR
Nuclear magnetic resonance
Older people
Oligodendrocytes
Organ Size
Physics
Physiological aspects
Physiology
Polymers
Propagation
Quantitative analysis
Shrinkage
Trends
Viscoelasticity
Viscosity
Young Adult
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Title The Influence of Physiological Aging and Atrophy on Brain Viscoelastic Properties in Humans
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