Matrix Metalloproteinase-2 and -9 Secreted by Leukemic Cells Increase the Permeability of Blood-Brain Barrier by Disrupting Tight Junction Proteins

• Published in: PloS one Vol. 6; no. 8; p. e20599
• Main Authors: Feng, Saran, Cen, Jiannong, Huang, Yihong, Shen, Hongjie, Yao, Li, Wang, Yuanyuan, Chen, Zixing
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 17.08.2011; Public Library of Science (PLoS)
• Subjects: Animal tissues; Animals; Biology; Blood-brain barrier; Blood-Brain Barrier - drug effects; Blood-Brain Barrier - metabolism; Brain; Brain - drug effects; Brain - metabolism; Brain - pathology; Brain cancer; Brain research; Cancer; Cell Line, Tumor; Central nervous system; Chemotherapy; Claudin-5; Claudins - metabolism; Dipeptides - pharmacology; Disruption; Edema; Endothelial cells; Endothelium; Extracellular matrix; Fluorescent Antibody Technique; Gelatin; Gelatinase A; Health aspects; Hematology; HL-60 Cells; Hospitals; Humans; Immunoblotting; Infiltration; Invasiveness; Ischemia; Laboratory animals; Leukemia; Leukemia - genetics; Leukemia - metabolism; Leukemia - pathology; Male; Matrix metalloproteinase; Matrix Metalloproteinase 2 - genetics; Matrix Metalloproteinase 2 - metabolism; Matrix Metalloproteinase 9 - genetics; Matrix Metalloproteinase 9 - metabolism; Medicine; Membrane permeability; Membrane Proteins - metabolism; Metalloproteinase; Metastases; Metastasis; Mice; Mice, Inbred BALB C; Microscopy, Confocal; Morbidity; Nervous system; Neuroimaging; Occludin; PCB; Permeability; Permeability - drug effects; Phosphoproteins - metabolism; Polychlorinated biphenyls; Protease Inhibitors - pharmacology; Proteins; Ribonucleic acid; RNA; RNA Interference; RNA-mediated interference; Thrombosis; Tight Junctions - drug effects; Tight Junctions - metabolism; Trends; U937 Cells; Zonula Occludens-1 Protein; China

Central nervous system (CNS) involvement remains an important cause of morbidity and mortality in acute leukemia, the mechanisms of leukemic cell infiltration into the CNS have not yet been elucidated. The blood-brain barrier (BBB) makes CNS become a refugee to leukemic cells and serves as a resourc...