Matrix Metalloproteinase-2 and -9 Secreted by Leukemic Cells Increase the Permeability of Blood-Brain Barrier by Disrupting Tight Junction Proteins - Feng, Saran; Cen, Jiannong; Huang, Yihong; Shen, Hongjie; Yao, Li; Wang, Yuanyuan; Chen, Zixing (PloS one, 2011)
Keywords: Animal tissues; Animals; Biology; Blood-brain barrier; Blood-Brain Barrier - drug effects; Blood-Brain Barrier - metabolism; Brain; Brain - drug effects; Brain - metabolism; Brain - pathology; Brain cancer; Brain research; Cancer; Cell Line, Tumor; Central nervous system; Chemotherapy; Claudin-5; Claudins - metabolism; Dipeptides - pharmacology; Disruption; Edema; Endothelial cells; Endothelium; Extracellular matrix; Fluorescent Antibody Technique; Gelatin; Gelatinase A; Health aspects; Hematology; HL-60 Cells; Hospitals; Humans; Immunoblotting; Infiltration; Invasiveness; Ischemia; Laboratory animals; Leukemia; Leukemia - genetics; Leukemia - metabolism; Leukemia - pathology; Male; Matrix metalloproteinase; Matrix Metalloproteinase 2 - genetics; Matrix Metalloproteinase 2 - metabolism; Matrix Metalloproteinase 9 - genetics; Matrix Metalloproteinase 9 - metabolism; Medicine; Membrane permeability; Membrane Proteins - metabolism; Metalloproteinase; Metastases; Metastasis; Mice; Mice, Inbred BALB C; Microscopy, Confocal; Morbidity; Nervous system; Neuroimaging; Occludin; PCB; Permeability; Permeability - drug effects; Phosphoproteins - metabolism; Polychlorinated biphenyls; Protease Inhibitors - pharmacology; Proteins; Ribonucleic acid; RNA; RNA Interference; RNA-mediated interference; Thrombosis; Tight Junctions - drug effects; Tight Junctions - metabolism; Trends; U937 Cells; Zonula Occludens-1 Protein; China