Metabolomics in Early Alzheimer's Disease: Identification of Altered Plasma Sphingolipidome Using Shotgun Lipidomics

• Published in: PloS one Vol. 6; no. 7; p. e21643
• Main Authors: Han, Xianlin, Rozen, Steve, Boyle, Stephen H., Hellegers, Caroline, Cheng, Hua, Burke, James R., Welsh-Bohmer, Kathleen A., Doraiswamy, P. Murali, Kaddurah-Daouk, Rima
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 11.07.2011; Public Library of Science (PLoS)
• Subjects: Abnormalities; Advertising executives; Aged; Aged, 80 and over; Aliphatic compounds; Alzheimer Disease - blood; Alzheimer Disease - genetics; Alzheimer's disease; Apolipoprotein E4; Apolipoproteins E - genetics; Apoptosis; Atherosclerosis; Atomic properties; Behavioral sciences; Biochemistry; Biology; Biomarkers; Brain; Brain research; Case-Control Studies; Ceramide; Ceramides; Chains; Chemistry; Cognitive ability; Correlation analysis; Dementia; Development and progression; Disruption; Female; Gene expression; Genotype; Genotype & phenotype; Health aspects; Humans; Hypotheses; Inflammation; Insulin resistance; Lipids; Male; Mass Spectrometry; Mass spectroscopy; Medical research; Medicine; Metabolism; Metabolomics; Metabolomics - methods; Middle Aged; Neurodegenerative diseases; Neurophysiology; Pathogenesis; Patients; Physiology; Plasma levels; Prospective Studies; Psychiatry; Reproducibility; Risk assessment; Sensitivity analysis; Shotguns; Species; Sphingolipids; Sphingolipids - blood; Sphingomyelin; Studies; North Carolina; Florida; United States > US

The development of plasma biomarkers could facilitate early detection, risk assessment and therapeutic monitoring in Alzheimer's disease (AD). Alterations in ceramides and sphingomyelins have been postulated to play a role in amyloidogensis and inflammatory stress related neuronal apoptosis; ho...