Metabolomics in Early Alzheimer's Disease: Identification of Altered Plasma Sphingolipidome Using Shotgun Lipidomics - Han, Xianlin; Rozen, Steve; Boyle, Stephen H.; Hellegers, Caroline; Cheng, Hua; Burke, James R.; Welsh-Bohmer, Kathleen A.; Doraiswamy, P. Murali; Kaddurah-Daouk, Rima (PloS one, 2011)
Keywords: Abnormalities; Advertising executives; Aged; Aged, 80 and over; Aliphatic compounds; Alzheimer Disease - blood; Alzheimer Disease - genetics; Alzheimer's disease; Apolipoprotein E4; Apolipoproteins E - genetics; Apoptosis; Atherosclerosis; Atomic properties; Behavioral sciences; Biochemistry; Biology; Biomarkers; Brain; Brain research; Case-Control Studies; Ceramide; Ceramides; Chains; Chemistry; Cognitive ability; Correlation analysis; Dementia; Development and progression; Disruption; Female; Gene expression; Genotype; Genotype & phenotype; Health aspects; Humans; Hypotheses; Inflammation; Insulin resistance; Lipids; Male; Mass Spectrometry; Mass spectroscopy; Medical research; Medicine; Metabolism; Metabolomics; Metabolomics - methods; Middle Aged; Neurodegenerative diseases; Neurophysiology; Pathogenesis; Patients; Physiology; Plasma levels; Prospective Studies; Psychiatry; Reproducibility; Risk assessment; Sensitivity analysis; Shotguns; Species; Sphingolipids; Sphingolipids - blood; Sphingomyelin; Studies; North Carolina; Florida; United States--US