Critical role of constitutive type I interferon response in bronchial epithelial cell to influenza infection

• Published in: PloS one Vol. 7; no. 3; p. e32947
• Main Authors: Hsu, Alan C-Y, Parsons, Kristy, Barr, Ian, Lowther, Sue, Middleton, Deborah, Hansbro, Philip M, Wark, Peter A B
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 02.03.2012; Public Library of Science (PLoS)
• Subjects: Analysis; Animals; Apoptosis; Avian influenza; Avian influenza viruses; Biological response modifiers; Biology; Bronchi - cytology; Bronchi - virology; Cell Line; Constraining; Cycloheximide - pharmacology; Disease susceptibility; Dogs; Endocytosis; Epithelial cells; Epithelial Cells - metabolism; Epithelial Cells - virology; Glycoproteins; Health aspects; Human behavior; Humans; Immune response; Immune system; Infection; Infections; Influenza; Influenza A Virus, H3N2 Subtype - metabolism; Influenza A Virus, H5N1 Subtype - metabolism; Influenza, Human - metabolism; Innate immunity; Interferon; Interferon Type I - metabolism; Interferon-beta - metabolism; Kinases; Medicine; Models, Biological; N-Acetylneuraminic Acid - chemistry; Organic acids; Pandemics; Protein Synthesis Inhibitors - pharmacology; Receptors; Replication; Respiratory tract; Signaling; Virus diseases; Virus replication; Viruses; Australia; New South Wales Australia

Innate antiviral responses in bronchial epithelial cells (BECs) provide the first line of defense against respiratory viral infection and the effectiveness of this response is critically dependent on the type I interferons (IFNs). However the importance of the antiviral responses in BECs during infl...