Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways

• Published in: PloS one Vol. 6; no. 2; p. e17286
• Main Authors: Thiagarajan, Rathi D, Georgas, Kylie M, Rumballe, Bree A, Lesieur, Emmanuelle, Chiu, Han Sheng, Taylor, Darrin, Tang, Dave T P, Grimmond, Sean M, Little, Melissa H
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 28.02.2011; Public Library of Science (PLoS)
• Subjects: Animals; Binding sites; Biology; Cell Compartmentation - genetics; Cluster Analysis; Collecting duct; Compartments; Data processing; Developmental biology; Diabetes; DNA binding proteins; DNA microarrays; Filtration; Gene expression; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genes; Genes, Developmental - physiology; Genetic research; Genomes; Geospatial data; Hepatocyte nuclear factor 4; Homeostasis; Kidney - embryology; Kidney - metabolism; Kidney diseases; Kidneys; Loop of Henle; Mammals; Mice; Models, Biological; Notch protein; Oligonucleotide Array Sequence Analysis; Ontology; Organogenesis; Organogenesis - genetics; Pattern formation; Retinoid X receptor α; Rodents; Segmentation; Signal transduction; Signal Transduction - genetics; Signal Transduction - physiology; Signaling; Spatial data; Tissue Distribution - genetics; Transcription (Genetics); Transcription factors; Ureter; Validation Studies as Topic; Australia

The development of the mammalian kidney is well conserved from mouse to man. Despite considerable temporal and spatial data on gene expression in mammalian kidney development, primarily in rodent species, there is a paucity of genes whose expression is absolutely specific to a given anatomical compa...