Simulation of Near-Infrared Light Absorption Considering Individual Head and Prefrontal Cortex Anatomy: Implications for Optical Neuroimaging

• Published in: PloS one Vol. 6; no. 10; p. e26377
• Main Authors: Haeussinger, Florian B., Heinzel, Sebastian, Hahn, Tim, Schecklmann, Martin, Ehlis, Ann-Christine, Fallgatter, Andreas J.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 24.10.2011; Public Library of Science (PLoS)
• Subjects: Absorption; Adult; Anatomy; Biology; Brain; Computer Science; Computer simulation; Cortex (frontal); Diagnostic imaging; Electromagnetic absorption; Head; Head - anatomy & histology; Hemodynamic responses; Hemodynamics; Humans; I.R. radiation; Infrared Rays; Infrared spectra; Infrared spectroscopy; Light; Light absorption; Magnetic Resonance Imaging; Medical imaging; Medicine; Microscopy; Monte Carlo Method; Monte Carlo methods; Monte Carlo simulation; Morphology; Near infrared radiation; Near infrared spectroscopy; Neuroimaging; Neurology; NMR; Nuclear magnetic resonance; Optics; Penetration depth; Physics; Prefrontal cortex; Prefrontal Cortex - anatomy & histology; Propagation; Psychiatry; Psychopathology; Psychotherapy; Scalp; Schizophrenia; Sensitivity; Sensors; Simulation; Sinus; Sinuses; Spectroscopy, Near-Infrared; Studies; Substantia grisea; Germany
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0026377

Functional near-infrared spectroscopy (fNIRS) is an established optical neuroimaging method for measuring functional hemodynamic responses to infer neural activation. However, the impact of individual anatomy on the sensitivity of fNIRS measuring hemodynamics within cortical gray matter is still unk...