The Lipid-Sensor Candidates CD36 and GPR120 Are Differentially Regulated by Dietary Lipids in Mouse Taste Buds: Impact on Spontaneous Fat Preference

• Published in: PloS one Vol. 6; no. 8; p. e24014
• Main Authors: Martin, Céline, Passilly-Degrace, Patricia, Gaillard, Dany, Merlin, Jean-François, Chevrot, Michaël, Besnard, Philippe
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 25.08.2011; Public Library of Science (PLoS)
• Subjects: Animals; Biology; Blotting, Western; CD36 antigen; CD36 Antigens - genetics; CD36 Antigens - metabolism; Chemoreception; Circadian Rhythm; Deactivation; Diet; Dietary Fats - pharmacology; Diurnal; Down-regulation; Experiments; Fatty acids; Food; Food intake; Food preferences; Food Preferences - drug effects; Food Preferences - physiology; Gene expression; Gene Expression - drug effects; Genes; Glycoproteins; Human subjects; Immunohistochemistry; Inactivation; Kinases; Laboratory animals; Lipids; Male; Medicine; Messenger RNA; Mice; Mice, Knockout; Motivation; Mutation; Nutrition; Obesity; Oral cavity; Papillae; Peptides; Pharmacology; Physiology; Post-transcription; Preferences; Protein folding; Proteins; Real-Time Polymerase Chain Reaction; Receptors; Receptors, G-Protein-Coupled - genetics; Receptors, G-Protein-Coupled - metabolism; Rodents; Satiety; Sensors; Sensory perception; Soybeans; Taste; Taste buds; Taste Buds - drug effects; Taste Buds - metabolism; Vegetable oils; France

Recent studies in rodents and humans suggest that the chemoreception of long-chain fatty acids (LCFA) in oral cavity is involved in the spontaneous preference for fatty foods and might contribute to the obesity risk. CD36 and GPR120 are LCFA receptors identified in rodent taste bud cells. The fact t...