Molecular mechanisms of thalidomide and its derivatives - ITO, Takumi; HANDA, Hiroshi (Proceedings of the Japan Academy, Series B, 2020)
Keywords: Animals; Beads; Blood cancer; cereblon; Chimeras; Cullin; Deoxyribonucleic acid; Derivatives; DNA; DNA repair; Drug Repositioning; Drugs; Enzymes; Erythema; FDA approval; Hematological diseases; Humans; immunomodulatory imide drugs (IMiDs); Immunotherapy; lenalidomide; Ligands; Lymphoma; Molecular modelling; Molecular Targeted Therapy; Multiple myeloma; Pharmaceutical industry; Proteins; Proteolysis; proteolysis targeting chimeras (PROTACs); Researchers; Review; Substrates; Teratogenicity; Thalidomide; Thalidomide - adverse effects; Thalidomide - chemistry; Thalidomide - pharmacology; Ubiquitin; Ubiquitin-protein ligase; United States--US; Japan; immunomodulatory imide drugs (IMiDs); cereblon; lenalidomide; thalidomide; ubiquitin; proteolysis targeting chimeras (PROTACs)