Different Oxidative Stress Response in Keratinocytes and Fibroblasts of Reconstructed Skin Exposed to Non Extreme Daily-Ultraviolet Radiation

• Published in: PloS one Vol. 5; no. 8; p. e12059
• Main Authors: Marionnet, Claire, Pierrard, Cécile, Lejeune, François, Sok, Juliette, Thomas, Marie, Bernerd, Françoise
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 10.08.2010; Public Library of Science (PLoS)
• Subjects: Analysis; Antioxidants; Biological effects; Biomarkers - metabolism; Biotechnology/Bioengineering; Cell Biology/Gene Expression; Cell Differentiation - radiation effects; Computer simulation; Deoxyribonucleic acid; Dermatologic Surgical Procedures; Dermatology; Dermis - cytology; Dermis - radiation effects; DNA; Epidermis - cytology; Epidermis - radiation effects; Exposure; Extreme ultraviolet radiation; Fibroblasts; Fibroblasts - cytology; Fibroblasts - metabolism; Fibroblasts - radiation effects; Gene expression; Gene Expression Profiling; Genomes; Histology; Humans; Irradiance; Keratinocytes; Keratinocytes - cytology; Keratinocytes - metabolism; Keratinocytes - radiation effects; Markers; Mitochondrial DNA; Modulation; Morphogenesis; Morphology; mRNA; Oxidative stress; Oxidative Stress - radiation effects; Physiological aspects; Physiology; Proteins; Pseudomonas aeruginosa; Radiation Dosage; Reconstructive Surgical Procedures; RNA; RNA, Messenger - genetics; RNA, Messenger - metabolism; Simulators; Skin; Skin - cytology; Skin - radiation effects; Solar simulators; Studies; Sun; Three dimensional models; Ultraviolet radiation; Ultraviolet Rays

Experiments characterizing the biological effects of sun exposure have usually involved solar simulators. However, they addressed the worst case scenario i.e. zenithal sun, rarely found in common outdoor activities. A non-extreme ultraviolet radiation (UV) spectrum referred as "daily UV radiati...