Increased Incidence and Clinical Picture of Childhood Narcolepsy following the 2009 H1N1 Pandemic Vaccination Campaign in Finland

• Published in: PloS one Vol. 7; no. 3; p. e33723
• Main Authors: Partinen, Markku, Saarenpää-Heikkilä, Outi, Ilveskoski, Ismo, Hublin, Christer, Linna, Miika, Olsén, Päivi, Nokelainen, Pekka, Alén, Reija, Wallden, Tiina, Espo, Merimaaria, Rusanen, Harri, Olme, Jan, Sätilä, Heli, Arikka, Harri, Kaipainen, Pekka, Julkunen, Ilkka, Kirjavainen, Turkka
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 28.03.2012; Public Library of Science (PLoS)
• Subjects: Adolescent; Adult; Adults; Age; Alleles; Cataplexy; Cataplexy - diagnosis; Cataplexy - epidemiology; Child; Child, Preschool; Childhood; Children; Children & youth; Confidence intervals; Drb1 protein; Environmental factors; Female; Finland - epidemiology; Histocompatibility antigen HLA; HLA-DQ beta-Chains - genetics; Hospitals; Humans; Incidence; Infections; Influenza A Virus, H1N1 Subtype - immunology; Influenza, Human - epidemiology; Influenza, Human - prevention & control; Inhabitants; Latency; Male; Medical diagnosis; Medicine; Narcolepsy; Narcolepsy - diagnosis; Narcolepsy - epidemiology; Neurology; Pandemics; Patients; REM sleep; Risk factors; Sleep; Sleep (REM); Sleep and wakefulness; Sleep disorders; Sleepiness; Studies; Swine flu; Vaccination; Vaccination - adverse effects; Vaccines; Young Adult; Finland

Narcolepsy is a rare neurological sleep disorder especially in children who are younger than 10 years. In the beginning of 2010, an exceptionally large number of Finnish children suffered from an abrupt onset of excessive daytime sleepiness (EDS) and cataplexy. Therefore, we carried out a systematic...