Alternative splicing and extensive RNA editing of human TPH2 transcripts

• Published in: PloS one Vol. 5; no. 1; p. e8956
• Main Authors: Grohmann, Maik, Hammer, Paul, Walther, Maria, Paulmann, Nils, Büttner, Andreas, Eisenmenger, Wolfgang, Baghai, Thomas C, Schüle, Cornelius, Rupprecht, Rainer, Bader, Michael, Bondy, Brigitta, Zill, Peter, Priller, Josef, Walther, Diego J
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 29.01.2010; Public Library of Science (PLoS)
• Subjects: Alternative Splicing; Amygdala; Analysis; B cells; Behavior disorders; Biochemistry/RNA Structure; Biochemistry/Transcription and Translation; Biology; Biosynthesis; Bipolar disorder; Brain; Cell lines; Central nervous system; Coding; Deregulation; Development and progression; Disorders; Drug abuse; Editing; Enzymatic activity; Enzymes; Etiology; Gene expression; Genes; Genetics; Haplotypes; Humans; Laboratories; Legal medicine; Mental depression; Mental disorders; Molecular Biology; Molecular Biology/RNA Splicing; Mood; Neurons; Neuroscience/Neural Homeostasis; Neuroscience/Neurobiology of Disease and Regeneration; Neuroscience/Neuronal Signaling Mechanisms; Neurosciences; Neurotransmission; Pharmacy; Physiological aspects; Psychiatry; Ribonucleic acid; RNA; RNA Editing; Schizophrenia; Serotonin; Suicide; Suicides & suicide attempts; Tryptophan; Tryptophan hydroxylase; Tryptophan Hydroxylase - genetics; Vertebrates; Germany

Brain serotonin (5-HT) neurotransmission plays a key role in the regulation of mood and has been implicated in a variety of neuropsychiatric conditions. Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of 5-HT. Recently, we discovered a second TPH isoform (TPH2) in verteb...