A Possible Contribution of Altered Cathepsin B Expression to the Development of Skin Sclerosis and Vasculopathy in Systemic Sclerosis - Noda, Shinji; Asano, Yoshihide; Akamata, Kaname; Aozasa, Naohiko; Taniguchi, Takashi; Takahashi, Takehiro; Ichimura, Yohei; Toyama, Tetsuo; Sumida, Hayakazu; Yanaba, Koichi; Tada, Yayoi; Sugaya, Makoto; et al. (PloS one, 2012)
Keywords: Angiogenesis; Animals; Antisense oligonucleotides; Arthritis; Autoimmune diseases; Biology; Blood vessels; Bone morphogenetic proteins; Calpain; Case-Control Studies; Cathepsin B; Cathepsin B - biosynthesis; Cathepsin B - physiology; Cathepsins; Collagen; Cytokines; Disease; Endothelial cells; Endothelial Cells - cytology; Enzyme-linked immunosorbent assay; Enzyme-Linked Immunosorbent Assay - methods; Extracellular matrix; Extracellular Matrix - metabolism; Female; Fibroblasts; Fibrosis; FLI1 protein; Gene expression; Gene Silencing; Genetic engineering; Humans; Laboratories; Male; Matrix metalloproteinases; Medical research; Medical schools; Medicine; Mice; Microcirculation; Microvasculature; Pathogenesis; Patients; Proteolysis; Rheumatology; Scleroderma; Scleroderma (Disease); Scleroderma, Systemic - metabolism; Scleroderma, Systemic - pathology; Skin; Skin - pathology; Statistical analysis; Stem cells; Systemic sclerosis; Transforming growth factor; Transforming Growth Factor beta - metabolism; Transforming growth factor-b; Transforming growth factor-b1; Transforming growth factors; Ulcers; Vascular diseases; Vascular Diseases - pathology; Vascular endothelial growth factor; United States--US; Japan