Revealing New Mouse Epicardial Cell Markers through Transcriptomics

• Published in: PloS one Vol. 5; no. 6; p. e11429
• Main Authors: Bochmann, Lars, Sarathchandra, Padmini, Mori, Federica, Lara-Pezzi, Enrique, Lazzaro, Domenico, Rosenthal, Nadia
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 28.06.2010; Public Library of Science (PLoS)
• Subjects: Analysis; Animal tissues; Animals; Basonuclin; Biomarkers; Cardiomyocytes; Cardiovascular Disorders/Myocardial Infarction; Cell Biology/Gene Expression; Cytokines; Deoxyribonucleic acid; DNA; DNA microarrays; Embryogenesis; Epicardium; Fibroblasts; Gene expression; Gene Expression Profiling; Gene Expression Regulation; Genes; Genetic engineering; Genomics; Glycoproteins; Growth factors; Heart; Heart attacks; Heart diseases; Heart surgery; Homeostasis; Infarction; Insulin-like growth factor I; Insulin-Like Growth Factor I - genetics; Laboratories; Mammals; Methyltransferases; Mice; Mice, Transgenic; Microscopy; Molecular Biology; Musculoskeletal system; Myocardial infarction; Myocardial Infarction - genetics; N6-methyladenosine; Oligonucleotide Array Sequence Analysis; Ontology; Pericardium - cytology; Progenitor cells; Proteins; Repair; Smooth muscle; Studies; Transcription; Transcription (Genetics); Transgenic mice; United Kingdom > UK; Italy

The epicardium has key functions during myocardial development, by contributing to the formation of coronary endothelial and smooth muscle cells, cardiac fibroblasts, and potentially cardiomyocytes. The epicardium plays a morphogenetic role by emitting signals to promote and maintain cardiomyocyte p...