Helicobacter pylori-induced histone modification, associated gene expression in gastric epithelial cells, and its implication in pathogenesis

• Published in: PloS one Vol. 5; no. 4; p. e9875
• Main Authors: Ding, Song-Ze, Fischer, Wolfgang, Kaparakis-Liaskos, Maria, Liechti, George, Merrell, D Scott, Grant, Patrick A, Ferrero, Richard L, Crowe, Sheila E, Haas, Rainer, Hatakeyama, Masanori, Goldberg, Joanna B
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.04.2010; Public Library of Science (PLoS)
• Subjects: Acetylation; Analysis; Antigens, Bacterial - genetics; Antigens, Bacterial - physiology; Antiulcer agents; Bacterial Proteins - genetics; Bacterial Proteins - physiology; Biological response modifiers; c-Jun protein; Carcinogens; Cell cycle; Cell proliferation; Cells, Cultured; Chemokines; Chromatin; Clinical isolates; Clonal deletion; Cytokines; Dephosphorylation; Disruption; Epithelial cells; Epithelial Cells - microbiology; Epithelial Cells - pathology; Flagella; Gastric Mucosa - microbiology; Gastric Mucosa - pathology; Gastroenterology and Hepatology/Gastrointestinal Cancers; Gastrointestinal diseases; Gene expression; Gene Expression Regulation; Genetic engineering; Genetic research; Genetics and Genomics/Epigenetics; Health aspects; Heat shock proteins; Helicobacter infections; Helicobacter Infections - pathology; Helicobacter pylori; Helicobacter pylori - pathogenicity; Histone H3; Histones - metabolism; Hsp70 protein; Humans; Immunology/Immunity to Infections; Infection; Infections; Infectious diseases; Infectious Diseases/Bacterial Infections; Infectious Diseases/Gastrointestinal Infections; Inflammation; Interferon; Interleukin 8; Ischemia; Kinases; Lysine; Medical research; Microbiology/Immunity to Infections; Mutants; Mutation; Pathogenesis; Pathogenicity; Pathogens; Phosphorylation; Polyamide-imides; Protein Processing, Post-Translational; Rodents; Serine; Signaling; Streptococcus infections; Transcription factors; Translocation; Trinucleotide repeats; United States > US; Virginia; Germany

Histone modifications are critical in regulating gene expression, cell cycle, cell proliferation, and development. Relatively few studies have investigated whether Helicobacter pylori, the major cause of human gastric diseases, affects histone modification. We therefore investigated the effects of H...