N-cofilin can compensate for the loss of ADF in excitatory synapses

• Published in: PloS one Vol. 6; no. 10; p. e26789
• Main Authors: Görlich, Andreas, Wolf, Michael, Zimmermann, Anika-Maria, Gurniak, Christine B, Al Banchaabouchi, Mumna, Sassoè-Pognetto, Marco, Witke, Walter, Friauf, Eckhard, Rust, Marco B
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 28.10.2011; Public Library of Science (PLoS)
• Subjects: Actin; Actins - metabolism; Animals; Biology; Brain; Cell culture; Cell cycle; Cofilin; Cofilin 1 - metabolism; Cofilin 1 - physiology; Depolymerization; Destrin - deficiency; Destrin - metabolism; Electron microscopy; Exocytosis; Experiments; Hippocampus; Hippocampus - cytology; Hippocampus - physiology; Homology; Immunocytochemistry; Immunoglobulins; Immunohistochemistry; Laboratory animals; Leukemia; LIM kinase; Lim Kinases; Memory; Mice; Microscopy, Electron; Morphology; Muscle proteins; Mutants; Neurobiology; Neurons; Neurosciences; Phosphorylation; Physiological aspects; Physiology; Plasticity; Presynaptic plasticity; Presynaptic Terminals; Proteins; Pyramidal cells; Pyramidal Cells - physiology; Receptors; Rodents; Synapses; Synaptic plasticity; Synaptic vesicles

Actin plays important roles in a number of synaptic processes, including synaptic vesicle organization and exocytosis, mobility of postsynaptic receptors, and synaptic plasticity. However, little is known about the mechanisms that control actin at synapses. Actin dynamics crucially depend on LIM kin...