NASA-Approved Rotary Bioreactor Enhances Proliferation of Human Epidermal Stem Cells and Supports Formation of 3D Epidermis-Like Structure

• Published in: PloS one Vol. 6; no. 11; p. e26603
• Main Authors: Lei, Xiao-hua, Ning, Li-na, Cao, Yu-jing, Liu, Shuang, Zhang, Shou-bing, Qiu, Zhi-fang, Hu, Hui-min, Zhang, Hui-shan, Liu, Shu, Duan, En-kui
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 09.11.2011; Public Library of Science (PLoS)
• Subjects: Analysis; Biology; Biomedical materials; Bioreactors; Bones; Carriers; Cell culture; Cell Culture Techniques; Cell cycle; Cell Differentiation - physiology; Cell growth; Cell Proliferation; Children; Colonies; Differentiation; Disease susceptibility; Efficiency; Epidermis; Epidermis - cytology; Epidermis - metabolism; FDA approval; Fluorescent Antibody Technique; Humans; Integrin beta1 - metabolism; Laboratories; Lei, Li; Medicine; Microgravity; R&D; Research & development; Skin; Stem cells; Stem Cells - cytology; Stem Cells - metabolism; Studies; Tissue engineering; Viability; Wound healing; Zoology; Beijing China; China

The skin is susceptible to different injuries and diseases. One major obstacle in skin tissue engineering is how to develop functional three-dimensional (3D) substitute for damaged skin. Previous studies have proved a 3D dynamic simulated microgravity (SMG) culture system as a "stimulatory"...