miRNA expression in colon polyps provides evidence for a multihit model of colon cancer

• Published in: PloS one Vol. 6; no. 6; p. e20465
• Main Authors: Oberg, Ann L, French, Amy J, Sarver, Aaron L, Subramanian, Subbaya, Morlan, Bruce W, Riska, Shaun M, Borralho, Pedro M, Cunningham, Julie M, Boardman, Lisa A, Wang, Liang, Smyrk, Thomas C, Asmann, Yan, Steer, Clifford J, Thibodeau, Stephen N
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 09.06.2011; Public Library of Science (PLoS)
• Subjects: Accounting; Adenoma; Adenoma - genetics; Analysis; Biology; Brain cancer; Cancer; Cancer genetics; Cell adhesion & migration; Chromosomes, Human, Pair 14 - genetics; Cluster Analysis; Colon; Colon - metabolism; Colon - pathology; Colon cancer; Colonic Neoplasms - genetics; Colonic Polyps - genetics; Colorectal cancer; Deactivation; Defects; Deoxyribonucleic acid; DNA; DNA repair; Epigenetics; Gene expression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genomes; Health sciences; Humans; Inactivation; Laboratories; Medicine; MicroRNA; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; Mismatch repair; MLH1 protein; Models, Biological; Mucosa; Ovarian cancer; Pathology; Physics; Polyps; Principal Component Analysis; Repair; Statistical analysis; Statistical methods; Stem cells; Subgroups; Transcription factors; Transformation; Tumors; United States > US; Minnesota

Changes in miRNA expression are a common feature in colon cancer. Those changes occurring in the transition from normal to adenoma and from adenoma to carcinoma, however, have not been well defined. Additionally, miRNA changes among tumor subgroups of colon cancer have also not been adequately evalu...