LINE-1 hypomethylation during primary colon cancer progression

• Published in: PloS one Vol. 6; no. 4; p. e18884
• Main Authors: Sunami, Eiji, de Maat, Michiel, Vu, Anna, Turner, Roderick R, Hoon, Dave S B
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 14.04.2011; Public Library of Science (PLoS)
• Subjects: Accuracy; Adenoma; Analysis; Biology; Biomarkers; Bisulfite; Breast cancer; Cancer; Care and treatment; Colon; Colon cancer; Colonic Neoplasms - genetics; Colonic Neoplasms - pathology; Colorectal cancer; Colorectal carcinoma; Demethylation; Deoxyribonucleic acid; Development and progression; Disease Progression; DNA; DNA Methylation; Epithelial cells; Epithelium; Genes; Genomes; Histopathology; Humans; Long Interspersed Nucleotide Elements; Lymphatic system; Medical prognosis; Medicine; Mesenchyme; Metastasis; Methylation; Oncology; Paraffin; Pathology; Patients; Quantitative analysis; Sodium; Stability analysis; Stem cells; Sulfites; Tumors; United States > US; California

Methylation levels of genomic repeats such as long interspersed nucleotide elements (LINE-1) are representative of global methylation status and play an important role in maintenance of genomic stability. The objective of the study was to assess LINE-1 methylation status in colorectal cancer (CRC) i...