Regulation of Brain-Derived Neurotrophic Factor Exon IV Transcription through Calcium Responsive Elements in Cortical Neurons

• Published in: PloS one Vol. 6; no. 12; p. e28441
• Main Authors: Zheng, Fei, Zhou, Xianju, Luo, Yongneng, Xiao, Hua, Wayman, Gary, Wang, Hongbing
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 09.12.2011; Public Library of Science (PLoS)
• Subjects: 1-Phosphatidylinositol 3-kinase; Activation; Analysis; Animals; Binding sites; Biology; Brain; Brain-derived neurotrophic factor; Brain-Derived Neurotrophic Factor - genetics; Ca2+/calmodulin-dependent protein kinase II; Ca2+/calmodulin-dependent protein kinase IV; Calcium; Calcium - pharmacology; Calcium channels; Calcium channels (L-type); Calcium channels (voltage-gated); Calcium Channels - metabolism; Calcium influx; Cerebral Cortex - cytology; Cyclic AMP Response Element-Binding Protein - metabolism; Exons - genetics; Gene Expression Regulation - drug effects; Glutamic acid receptors (ionotropic); Kinases; Luciferases - metabolism; Models, Biological; Mutation; N-Methyl-D-aspartic acid receptors; N-Methylaspartate - pharmacology; Neurons; Neurons - drug effects; Neurons - metabolism; Neuroplasticity; Plasmids; Plasticity; Potassium Chloride - pharmacology; Protein kinase A; Protein kinases; Protein Kinases - metabolism; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate - metabolism; Response Elements - genetics; RNA, Messenger - genetics; RNA, Messenger - metabolism; Signal Transduction - drug effects; Signal Transduction - genetics; Transcription (Genetics); Transcription, Genetic - drug effects; United States > US; East Lansing Michigan; Michigan

Activity-dependent transcription of brain-derived neurotrophic factor (BDNF) has been studied as an important model to elucidate the mechanisms underlying numerous aspects of neuroplasticity. It has been extensively emphasized that Ca(2+) influx through different routes may have significantly differ...