Functional interaction between acyl-CoA synthetase 4, lipooxygenases and cyclooxygenase-2 in the aggressive phenotype of breast cancer cells

• Published in: PloS one Vol. 5; no. 11; p. e15540
• Main Authors: Maloberti, Paula M, Duarte, Alejandra B, Orlando, Ulises D, Pasqualini, María E, Solano, Angela R, López-Otín, Carlos, Podestá, Ernesto J
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 11.11.2010; Public Library of Science (PLoS)
• Subjects: Aggressive behavior; Antibiotics; Apoptosis; Arachidonate 12-Lipoxygenase - genetics; Arachidonate 12-Lipoxygenase - metabolism; Arachidonic acid; Arachidonic Acid - metabolism; Biochemistry; Biology; Biosynthesis; Blotting, Western; Breast cancer; Breast Neoplasms - enzymology; Breast Neoplasms - genetics; Breast Neoplasms - pathology; Cancer; Cancer cells; Cell cycle; Cell growth; Cell Line, Tumor; Cell Movement; Cell Proliferation; Coenzyme A Ligases - genetics; Coenzyme A Ligases - metabolism; Colon; Colon cancer; COX-2 inhibitors; Cyclooxygenase 2 - genetics; Cyclooxygenase 2 - metabolism; Cyclooxygenase-2; Drugs; Enzymes; Esterification; Fatty acids; Fatty Acids - metabolism; Gene Expression Profiling; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Genetic aspects; Genotype & phenotype; Hepatocellular carcinoma; Humans; Intracellular levels; Kinases; Ligases; Lipoxygenases - genetics; Lipoxygenases - metabolism; Liver cancer; Medicine; Metabolism; Metabolites; Metastases; Metastasis; Mitochondria; Mitochondria - metabolism; Motility; Phosphorylation; Physiological aspects; Prostaglandins - metabolism; Proteins; Regulation; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Rodents; Side effects; Trends; Tumorigenesis

The acyl-CoA synthetase 4 (ACSL4) is increased in breast cancer, colon and hepatocellular carcinoma. ACSL4 mainly esterifies arachidonic acid (AA) into arachidonoyl-CoA, reducing free AA intracellular levels, which is in contradiction with the need for AA metabolites in tumorigenesis. Therefore, the...