Brown Adipose Tissue in Morbidly Obese Subjects

• Published in: PloS one Vol. 6; no. 2; p. e17247
• Main Authors: Vijgen, Guy H. E. J., Bouvy, Nicole D., Teule, G. J. Jaap, Brans, Boudewijn, Schrauwen, Patrick, van Marken Lichtenbelt, Wouter D.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 24.02.2011; Public Library of Science (PLoS)
• Subjects: Adipocytes; Adipose tissue; Adipose tissue (brown); Adipose Tissue, Brown - metabolism; Adipose Tissue, Brown - physiology; Adolescent; Adult; Biology; Body composition; Body fat; Body mass; Body Mass Index; Body size; Body Temperature Regulation - physiology; Care and treatment; CAT scans; Cold; Cold Temperature; Computed tomography; Cooling; Diabetes; Energy expenditure; Energy Metabolism - physiology; Exposure; Female; Health aspects; Humans; Male; Medicine; Metabolism; Middle Aged; Non-shivering; Nuclear medicine; Nutrition research; Obesity; Obesity, Morbid - metabolism; Obesity, Morbid - physiopathology; Physiological aspects; Positron emission; Positron emission tomography; Rodents; Shivering; Skin; Skin Temperature - physiology; Studies; Thermogenesis; Thermogenesis - physiology; Toxicology; Young Adult; Netherlands

Cold-stimulated adaptive thermogenesis in brown adipose tissue (BAT) to increase energy expenditure is suggested as a possible therapeutic target for the treatment of obesity. We have recently shown high prevalence of BAT in adult humans, which was inversely related to body mass index (BMI) and body...