Myocardial Alternative RNA Splicing and Gene Expression Profiling in Early Stage Hypoplastic Left Heart Syndrome

• Published in: PloS one Vol. 7; no. 1; p. e29784
• Main Authors: Ricci, Marco, Xu, Yanji, Hammond, Harriet L., Willoughby, David A., Nathanson, Lubov, Rodriguez, Maria M., Vatta, Matteo, Lipshultz, Steven E., Lincoln, Joy
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 27.01.2012; Public Library of Science (PLoS)
• Subjects: Alternative splicing; Alternative Splicing - genetics; Analysis; Arthritis; Bioinformatics; Biological activity; Biology; Biomarkers; Birth defects; Cardiology; Cardiovascular diseases; Case-Control Studies; Cell adhesion; Children & youth; Cluster Analysis; Clustering; Colorectal cancer; Coronary artery disease; Cytoskeleton; Deoxyribonucleic acid; Diagnostic systems; DNA; Female; Gene expression; Gene Expression Profiling; Genes; Genetic disorders; Genetic engineering; Genomes; Genomics; Gestational Age; Heart; Heart diseases; Heart failure; Hospitals; Humans; Hypoplastic left heart syndrome; Hypoplastic Left Heart Syndrome - genetics; Hypoplastic Left Heart Syndrome - metabolism; Hypoplastic Left Heart Syndrome - pathology; Infant, Newborn; Lung cancer; Male; Medical research; Medicine; Messenger RNA; Metabolism; Microarray Analysis; Myocardium; Myocardium - metabolism; Myocardium - pathology; Neonates; Newborn babies; Pediatrics; Phosphorylation; Questioning; Regulatory mechanisms (biology); Reverse Transcriptase Polymerase Chain Reaction; Ribonucleic acid; RNA; RNA, Messenger - metabolism; Skin diseases; Studies; Transcription; Transcription (Genetics); Validation Studies as Topic; Ventricle; Ohio; Florida; United States > US; Texas
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0029784

Hypoplastic Left Heart Syndrome (HLHS) is a congenital defect characterized by underdevelopment of the left ventricle and pathological compensation of the right ventricle. If untreated, HLHS is invariably lethal due to the extensive increase in right ventricular workload and eventual failure. Despit...