Mitochondrial 12s rRNA mutation A1555G: validation of a genotyping method

BACKGROUND: Research established a genetic basis for aminoglycoside-induced hearing loss (HL) through sequence analysis of the mitochondrial genome, which resulted in the characterization of mutations in the human 12S rRNA that are correlated with aminoglycoside induced ototoxicity. The most common...

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Bibliographic Details
Published inMinerva Biotechnology and Biomolecular Research Vol. 34; no. 2; p. 49
Main Authors DAPRÀ, Valentina, GALLIANO, Ilaria, ALLIAUDI, Carla, CALVI, Cristina, ALBANO, Alessia, SAVIO, Elena, SAVINO, Francesco, BERGALLO, Massimiliano
Format Journal Article
LanguageEnglish
Published Torino Edizioni Minerva Medica 01.06.2022
Subjects
Alleles
Aminoglycoside antibiotics
Antibiotics
Genomes
Genotyping
Hearing loss
Mitochondria
Mutation
Nucleotide sequence
Ototoxicity
Patients
Polymerase chain reaction
rRNA 12S
Sequence analysis
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ISSN2724-542X
1120-4826
2724-5934
1827-160X
DOI10.23736/S2724-542X.21.02746-4

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