Reduced airborne transmission of SARS-CoV-2 BA.1 Omicron virus in Syrian hamsters

JRP and VJM are supported by the Intramural Research Program of the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH). The authors report no other conflict of interest. Since the start of the COVID-19 pandemic, Severe Acute Respiratory Syndrome Corona...

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Published inPLOS Pathogens Vol. 18; no. 12; p. e1010970
Main Authors Boon, Adrianus C. M., Darling, Tamarand L., Halfmann, Peter J., Franks, John, Webby, Richard J., Barouch, Dan H., Port, Julia R., Munster, Vincent J., Diamond, Michael S., Kawaoka, Yoshihiro
Format Journal Article
LanguageEnglish
Published United States Public Library of Science (PLoS) 02.12.2022
Public Library of Science
Subjects
Airborne infection
Allergies
Animal experimentation
Animal models in research
Animals
Biology (General)
Biology and Life Sciences
Conflicts of interest
Coronaviruses
COVID-19
Cricetinae
Disease transmission
Funding
Hamsters
Immunologic diseases. Allergy
Infectious diseases
Influenza
Intermediates
Laboratories
Medical research
Medicine and health sciences
Medicine, Experimental
Mesocricetus
Methods
Mutation
Opinion
Pandemics
Physiological aspects
Proteins
QH301-705.5
R&D
RC581-607
Research & development
Research and Analysis Methods
Respiratory Aerosols and Droplets
SARS-CoV-2
Seroconversion
Severe acute respiratory syndrome coronavirus 2
Spike protein
Vaccines
Viral diseases
Viruses
United States
Japan
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Abstract JRP and VJM are supported by the Intramural Research Program of the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH). The authors report no other conflict of interest. Since the start of the COVID-19 pandemic, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has caused hundreds of millions of infections worldwide with more than 6.5 million confirmed deaths. Transmission of SARS-CoV-2 can be established by detection of viral RNA, RNA replication intermediates, viable infectious virus, or seroconversion, with the latter two metrics being the most stringent. Since January 2021, the National Institutes of Health SARS-CoV-2 Assessment of Variant Evolution (SAVE) initiative has evaluated the transmission potential of SARS-CoV-2 variants in Syrian hamsters [16]. [...]it is possible that the changes in the spike protein of Omicron affect and reduce stability of the virus in the infected hosts.
AbstractList JRP and VJM are supported by the Intramural Research Program of the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH). The authors report no other conflict of interest. Since the start of the COVID-19 pandemic, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has caused hundreds of millions of infections worldwide with more than 6.5 million confirmed deaths. Transmission of SARS-CoV-2 can be established by detection of viral RNA, RNA replication intermediates, viable infectious virus, or seroconversion, with the latter two metrics being the most stringent. Since January 2021, the National Institutes of Health SARS-CoV-2 Assessment of Variant Evolution (SAVE) initiative has evaluated the transmission potential of SARS-CoV-2 variants in Syrian hamsters [16]. [...]it is possible that the changes in the spike protein of Omicron affect and reduce stability of the virus in the infected hosts.
JRP and VJM are supported by the Intramural Research Program of the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH). The authors report no other conflict of interest. Since the start of the COVID-19 pandemic, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has caused hundreds of millions of infections worldwide with more than 6.5 million confirmed deaths. Transmission of SARS-CoV-2 can be established by detection of viral RNA, RNA replication intermediates, viable infectious virus, or seroconversion, with the latter two metrics being the most stringent. Since January 2021, the National Institutes of Health SARS-CoV-2 Assessment of Variant Evolution (SAVE) initiative has evaluated the transmission potential of SARS-CoV-2 variants in Syrian hamsters [16]. [...]it is possible that the changes in the spike protein of Omicron affect and reduce stability of the virus in the infected hosts.
Audience Academic
Author Tamarand L. Darling
Michael S. Diamond
John Franks
Adrianus C. M. Boon
Yoshihiro Kawaoka
Vincent J. Munster
Peter J. Halfmann
Julia R. Port
Dan H. Barouch
Richard J. Webby
AuthorAffiliation 5 Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
4 Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, United States of America
11 The Research Center for Global Viral Diseases, National Center for Global Health and Medicine Research Institute, Tokyo, Japan
10 Department of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
2 Department of Pathology and Immunology Washington University School of Medicine in St. Louis, Missouri, United States of America
7 Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, United States of America
Boston Children’s Hospital, UNITED STATES
1 Department of Medicine, Washington University School of Medicine in St. Louis, Missouri, United States of America
8 Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of He
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– name: 6 Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
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I have read the journal’s policy and the authors of this manuscript have the following competing interests: D.H.B is a co-inventor on provisional vaccine patents (63/121,482; 63/133,969; 63/135,182). The Boon laboratory has received unrelated funding support in sponsored research agreements from AI Therapeutics, GreenLight Biosciences Inc., and Nano targeting & Therapy Biopharma Inc. The Boon laboratory has received funding support from AbbVie Inc., for the commercial development of SARS-CoV-2 mAb. M.S.D. is a consultant for Inbios, Vir Biotechnology, Senda Biosciences, and Carnival Corporation, on the Scientific Advisory Boards of Moderna and Immunome, and has licensed mucosal vaccine technology to Bharat Biotech and Ocugen. The Diamond laboratory has received unrelated funding support in sponsored research agreements from Vir Biotechnology, Kaleido, and Emergent BioSolutions and past support from Moderna not related to these studies. The authors report no other conflict of interest.
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SubjectTerms Airborne infection
Allergies
Animal experimentation
Animal models in research
Animals
Biology (General)
Biology and Life Sciences
Conflicts of interest
Coronaviruses
COVID-19
Cricetinae
Disease transmission
Funding
Hamsters
Immunologic diseases. Allergy
Infectious diseases
Influenza
Intermediates
Laboratories
Medical research
Medicine and health sciences
Medicine, Experimental
Mesocricetus
Methods
Mutation
Opinion
Pandemics
Physiological aspects
Proteins
QH301-705.5
R&D
RC581-607
Research & development
Research and Analysis Methods
Respiratory Aerosols and Droplets
SARS-CoV-2
Seroconversion
Severe acute respiratory syndrome coronavirus 2
Spike protein
Vaccines
Viral diseases
Viruses
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Title Reduced airborne transmission of SARS-CoV-2 BA.1 Omicron virus in Syrian hamsters
URI https://cir.nii.ac.jp/crid/1871991017685355776
https://www.ncbi.nlm.nih.gov/pubmed/36459536
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Volume 18
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