Tyk2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on non-autoimmune complex traits - Diogo, Dorothée; Bastarache, Lisa; Liao, Katherine P.; Graham, Robert R.; Fulton, Robert S.; Greenberg, Jeffrey D.; Eyre, Steve; Bowes, John; Cui, Jing; Lee, Annette; Pappas, Dimitrios A.; Kremer, Joel M.; et al. (PloS one, 2015)
Keywords: Analysis; Arthritis; Arthritis, Rheumatoid - enzymology; Arthritis, Rheumatoid - genetics; Autoimmune diseases; Autoimmunity; Autoimmunity - genetics; Biological effects; Cell Adhesion Molecules - genetics; Chromosome 19; Chronic conditions; Electronic Health Records; Electronic medical records; Exons - genetics; Gastrointestinal diseases; Genetic Loci - genetics; Genetic Pleiotropy; Genetic Predisposition to Disease - genetics; Genome-wide association studies; Genomes; Genomics; Genotyping; Humans; Inflammatory bowel diseases; Intestine; Loci; Medical treatment; Pathogenesis; Polymorphism, Single Nucleotide; Protein-tyrosine kinase; Rheumatoid arthritis; Rheumatoid factor; Systemic lupus erythematosus; TYK2 Kinase - genetics; Tyk2 protein; Tyrosine