Mammalian O-mannosyl glycans: Biochemistry and glycopathology
Glycosylation is an important posttranslational modification in mammals. The glycans of glycoproteins are classified into two groups, namely, N-glycans and O-glycans, according to their glycan-peptide linkage regions. Recently, O-mannosyl glycan, an O-glycan, has been shown to be important in muscle...
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| Published in | Proceedings of the Japan Academy, Series B Vol. 95; no. 1; pp. 39 - 51 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
Japan
The Japan Academy
01.01.2019
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0386-2208 1349-2896 1349-2896 |
| DOI | 10.2183/pjab.95.004 |
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| Abstract | Glycosylation is an important posttranslational modification in mammals. The glycans of glycoproteins are classified into two groups, namely, N-glycans and O-glycans, according to their glycan-peptide linkage regions. Recently, O-mannosyl glycan, an O-glycan, has been shown to be important in muscle and brain development. A clear relationship between O-mannosyl glycans and the pathomechanisms of some congenital muscular dystrophies has been established in humans. Ribitol-5-phosphate is a newly identified glycan component in mammals, and its biosynthetic pathway has been elucidated. The discovery of new glycan structures and the identification of highly regulated mechanisms of glycan processing will help researchers to understand glycan functions and develop therapeutic strategies. |
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| AbstractList | Glycosylation is an important posttranslational modification in mammals. The glycans of glycoproteins are classified into two groups, namely, N-glycans and O-glycans, according to their glycan-peptide linkage regions. Recently, O-mannosyl glycan, an O-glycan, has been shown to be important in muscle and brain development. A clear relationship between O-mannosyl glycans and the pathomechanisms of some congenital muscular dystrophies has been established in humans. Ribitol-5-phosphate is a newly identified glycan component in mammals, and its biosynthetic pathway has been elucidated. The discovery of new glycan structures and the identification of highly regulated mechanisms of glycan processing will help researchers to understand glycan functions and develop therapeutic strategies. Glycosylation is an important posttranslational modification in mammals. The glycans of glycoproteins are classified into two groups, namely, N -glycans and O -glycans, according to their glycan-peptide linkage regions. Recently, O -mannosyl glycan, an O -glycan, has been shown to be important in muscle and brain development. A clear relationship between O -mannosyl glycans and the pathomechanisms of some congenital muscular dystrophies has been established in humans. Ribitol-5-phosphate is a newly identified glycan component in mammals, and its biosynthetic pathway has been elucidated. The discovery of new glycan structures and the identification of highly regulated mechanisms of glycan processing will help researchers to understand glycan functions and develop therapeutic strategies. Glycosylation is an important posttranslational modification in mammals. The glycans of glycoproteins are classified into two groups, namely, N-glycans and O-glycans, according to their glycan-peptide linkage regions. Recently, O-mannosyl glycan, an O-glycan, has been shown to be important in muscle and brain development. A clear relationship between O-mannosyl glycans and the pathomechanisms of some congenital muscular dystrophies has been established in humans. Ribitol-5-phosphate is a newly identified glycan component in mammals, and its biosynthetic pathway has been elucidated. The discovery of new glycan structures and the identification of highly regulated mechanisms of glycan processing will help researchers to understand glycan functions and develop therapeutic strategies.Glycosylation is an important posttranslational modification in mammals. The glycans of glycoproteins are classified into two groups, namely, N-glycans and O-glycans, according to their glycan-peptide linkage regions. Recently, O-mannosyl glycan, an O-glycan, has been shown to be important in muscle and brain development. A clear relationship between O-mannosyl glycans and the pathomechanisms of some congenital muscular dystrophies has been established in humans. Ribitol-5-phosphate is a newly identified glycan component in mammals, and its biosynthetic pathway has been elucidated. The discovery of new glycan structures and the identification of highly regulated mechanisms of glycan processing will help researchers to understand glycan functions and develop therapeutic strategies. |
| Author | ENDO, Tamao |
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| Keywords | O-mannosylation congenital muscular dystrophy dystroglycan ribitol-5-phosphate |
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| Snippet | Glycosylation is an important posttranslational modification in mammals. The glycans of glycoproteins are classified into two groups, namely, N-glycans and... Glycosylation is an important posttranslational modification in mammals. The glycans of glycoproteins are classified into two groups, namely, N -glycans and O... |
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| SubjectTerms | Animals Biochemistry Brain congenital muscular dystrophy Disease dystroglycan Enzymes Glycan Glycoproteins Glycosylation Gram-positive bacteria Humans Mammals Mannose - chemistry Muscles Muscular dystrophy Musculoskeletal system Mutation N-glycans O-mannosylation Peptides Phosphorylation Polysaccharides Polysaccharides - biosynthesis Polysaccharides - chemistry Polysaccharides - metabolism Proteins Researchers Review ribitol-5-phosphate |
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| Title | Mammalian O-mannosyl glycans: Biochemistry and glycopathology |
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| ispartofPNX | Proceedings of the Japan Academy, Series B, 2019/01/11, Vol.95(1), pp.39-51 |
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