Safety and efficacy of long-term nicotinamide mononucleotide supplementation on metabolism, sleep, and nicotinamide adenine dinucleotide biosynthesis in healthy, middle-aged Japanese men

• Published in: ENDOCRINE JOURNAL Vol. 71; no. 2; pp. 153 - 169
• Main Authors: Yamaguchi, Shintaro, Irie, Junichiro, Mitsuishi, Masanori, Uchino, Yuichi, Nakaya, Hideaki, Takemura, Ryo, Inagaki, Emi, Kosugi, Shotaro, Okano, Hideyuki, Yasui, Masato, Tsubota, Kazuo, Hayashi, Kaori, Yoshino, Jun, Itoh, Hiroshi
• Format: Journal Article
• Language: English
• Published: Japan The Japan Endocrine Society 01.01.2024; Japan Science and Technology Agency
• Subjects: Aging; Animal models; Biosynthesis; Cardiovascular disease; Coronary artery disease; Heart diseases; Hyperinsulinemia; Leukocytes (mononuclear); Metabolism; Middle age; NAD; Nicotinamide adenine dinucleotide; Nicotinamide mononucleotide; Obesity; Oral administration; Peripheral blood mononuclear cells; Postprandial hyperinsulinemia; Risk factors; Sleep; Nicotinamide adenine dinucleotide; Postprandial hyperinsulinemia; Metabolism; Nicotinamide mononucleotide

Obesity and aging are major risk factors for several life-threatening diseases. Accumulating evidence from both rodents and humans suggests that the levels of nicotinamide adenine dinucleotide (NAD+), a regulator of many biological processes, declines in multiple organs and tissues with aging and ob...