Eosinophil and neutrophil extracellular DNA traps in human allergic asthmatic airways

• Published in: Journal of allergy and clinical immunology Vol. 127; no. 5; pp. 1260 - 1266
• Main Authors: Dworski, Ryszard, Simon, Hans-Uwe, Hoskins, Aimee, Yousefi, Shida
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.05.2011; Elsevier; Elsevier Limited
• Subjects: Adult; allergens; Allergens - immunology; Allergies; Allergy and Immunology; Animals; antibodies; Asthma; Asthma - immunology; Asthma - metabolism; Asthma - physiopathology; Atopic asthma; Biological and medical sciences; biomarker; Biopsy; bronchoalveolar lavage fluid; chemokines; Chronic obstructive pulmonary disease, asthma; Cytotoxicity; Deoxyribonucleic acid; DNA; DNA - metabolism; eosinophils; Eosinophils - immunology; Eosinophils - metabolism; extracellular DNA traps; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; human; Humans; Hypersensitivity, Immediate - immunology; Hypersensitivity, Immediate - metabolism; Hypersensitivity, Immediate - physiopathology; Immunopathology; inflammation; interferon-gamma; interleukin-5; iodine; Lung - immunology; Lung - metabolism; Lung - physiopathology; lungs; Male; Medical sciences; neutrophils; Neutrophils - immunology; Neutrophils - metabolism; phenotype; Pneumology; propidium; Proteins; quantitative analysis; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Studies; Young Adult; Atopic asthma; Atp6; eosinophils; biomarker; Gapdh; BAL; C5a; extracellular DNA traps; ECP; EET; bronchoalveolar lavage fluid; MBP; NET; human; neutrophils; hpf; Major basic protein; Eosinophil extracellular trap; Complement 5a; ATP synthase subunit 6 gene; Bronchoalveolar lavage; High-power field; Neutrophil extracellular trap; Eosinophil cationic protein; Glyceraldehyde-3-phosphate dehydrogenase gene; Allergy; Granulocyte; Biological marker; bio-marker; Respiratory system; Atopy; Respiratory tract; Immunology; Bronchus disease; Obstructive pulmonary disease; Human; Lung disease; Immunopathology; Respiratory disease; Extracellular; Eosinophil; Asthma; DNA; Neutrophil

Asthma is a heterogeneous inflammatory airway disorder that involves eosinophilic and noneosinophilic phenotypes. Unlike in healthy lungs, eosinophils are often present in atopic asthmatic airways, although a subpopulation of asthmatic subjects predominantly experience neutrophilic inflammation. Rec...