Antibody recognition of the Pneumovirus fusion protein trimer interface

• Published in: PLoS pathogens Vol. 16; no. 10; p. e1008942
• Main Authors: Huang, Jiachen, Diaz, Darren, Mousa, Jarrod J.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 09.10.2020; Public Library of Science (PLoS)
• Subjects: Antibodies; Antibodies, Monoclonal - immunology; Antibodies, Neutralizing - immunology; Antibodies, Neutralizing - pharmacology; Antibodies, Viral - immunology; Antigens; BASIC BIOLOGICAL SCIENCES; Biology and Life Sciences; Crystallization; Engineering and Technology; Epidemics; Epitopes; Epitopes - immunology; F 2 region; F protein; Fusion protein; Genetic aspects; Glycan; Glycoproteins; Health aspects; Host-virus relationships; Human subjects; Humans; Identification and classification; Immune response; Immune response (humoral); Immune system; Immunocompromised hosts; Immunology; Infants; Infections; Infectious diseases; Interferometry; Medicine and Health Sciences; Metapneumovirus - immunology; Monoclonal antibodies; Mutation; Neutralization; Neutralizing; Paramyxoviridae Infections - virology; Peptides; Physical Sciences; Pneumovirus - immunology; Proteins; Recognition; Research and Analysis Methods; Respiratory diseases; Respiratory syncytial virus; Respiratory Syncytial Virus, Human - immunology; Respiratory tract; Respiratory tract diseases; RNA viruses; Severe acute respiratory syndrome coronavirus 2; Trimers; Vaccines; Veterinary colleges; Veterinary medicine; Viral Fusion Proteins - immunology; Viral infections; Viral proteins; Viruses; United States; United States > US

Human metapneumovirus (hMPV) is a leading cause of viral respiratory infection in children, and can cause severe lower respiratory tract infection in infants, the elderly, and immunocompromised patients. However, there remain no licensed vaccines or specific treatments for hMPV infection. Although t...