The Influence of Atorvastatin Treatment on Homocysteine Metabolism and Oxidative Stress in an Experimental Model of Diabetic Rats

Objective: In our experimental study, we evaluated the influence of treatment with atorvastatin on the antioxidant activity of intracellular and extracellular systems factors, homocysteine levels (Hcy), and lipid profiles in obese and diabetic rats. Method: Twenty-one male Wistar rats, aged 6 months...

Full description

Saved in:
Bibliographic Details
Published inLife (Basel, Switzerland) Vol. 14; no. 11; p. 1414
Main Authors Clim, Andreea, Maranduca, Minela Aida, Filip, Nina, Tănase, Daniela Maria, Floria, Mariana, Pinzariu, Alin Constantin, Popa, Irene Paula, Nemteanu, Roxana, Cozma, Tudor Cristian, Faur, Flaviu Ionut, Serban, Dragomir Nicolae, Scripcariu, Dragoș Viorel, Serban, Ionela Lacramioara
Format Journal Article
LanguageEnglish
Published 02.11.2024
Online AccessGet full text

Cover

Abstract Objective: In our experimental study, we evaluated the influence of treatment with atorvastatin on the antioxidant activity of intracellular and extracellular systems factors, homocysteine levels (Hcy), and lipid profiles in obese and diabetic rats. Method: Twenty-one male Wistar rats, aged 6 months, 450–550 g, were allocated into three groups. From the beginning of the study, the first group (G-I, control) received only standard food, while the second and third groups (G II—obese, G III—diabetic) were administered a high-fat diet (HFD) with 2% cholesterol. After 2 weeks of accommodation, the specimens in G-III were injected intraperitoneal (i.p.) streptozotocin (35 mg of body weight, pH 4.5), intervention followed by the onset of type 2 diabetes mellitus. Following confirmation of diabetes onset, the specimens in G III were administered concomitantly with the HFD a daily gavage of atorvastatin 20 mg of body weight/day for 20 days. We measured, at the beginning and the end of the study, the Hcy levels, lipid profile, vitamin B12, B6, folic acid, and various parameters of oxidative stress (OS)—total antioxidant status (TAS), glutathione peroxidase (GPX) and superoxide dismutase (SOD). Results: After treatment with atorvastatin, the lipid profile in G III significantly improved compared to the other two groups, but enzymatic markers of oxidative stress did not closely parallel this trend. However, after the treatment of statin, we observed an important reduction in Hcy values. Conclusion: Our results demonstrate that treatment with atorvastatin can be used not only for its lipid-lowering properties and antioxidant effects but also to reduce Hcy concentration in this experimental model of diabetic rats. Moreover, atorvastatin therapy improves lipid profiles, reduces inflammation, suppresses oxidation, and decreases Hcy levels, potentially preventing major adverse cardiovascular events.
AbstractList Objective: In our experimental study, we evaluated the influence of treatment with atorvastatin on the antioxidant activity of intracellular and extracellular systems factors, homocysteine levels (Hcy), and lipid profiles in obese and diabetic rats. Method: Twenty-one male Wistar rats, aged 6 months, 450–550 g, were allocated into three groups. From the beginning of the study, the first group (G-I, control) received only standard food, while the second and third groups (G II—obese, G III—diabetic) were administered a high-fat diet (HFD) with 2% cholesterol. After 2 weeks of accommodation, the specimens in G-III were injected intraperitoneal (i.p.) streptozotocin (35 mg of body weight, pH 4.5), intervention followed by the onset of type 2 diabetes mellitus. Following confirmation of diabetes onset, the specimens in G III were administered concomitantly with the HFD a daily gavage of atorvastatin 20 mg of body weight/day for 20 days. We measured, at the beginning and the end of the study, the Hcy levels, lipid profile, vitamin B12, B6, folic acid, and various parameters of oxidative stress (OS)—total antioxidant status (TAS), glutathione peroxidase (GPX) and superoxide dismutase (SOD). Results: After treatment with atorvastatin, the lipid profile in G III significantly improved compared to the other two groups, but enzymatic markers of oxidative stress did not closely parallel this trend. However, after the treatment of statin, we observed an important reduction in Hcy values. Conclusion: Our results demonstrate that treatment with atorvastatin can be used not only for its lipid-lowering properties and antioxidant effects but also to reduce Hcy concentration in this experimental model of diabetic rats. Moreover, atorvastatin therapy improves lipid profiles, reduces inflammation, suppresses oxidation, and decreases Hcy levels, potentially preventing major adverse cardiovascular events.
Author Popa, Irene Paula
Serban, Ionela Lacramioara
Tănase, Daniela Maria
Filip, Nina
Pinzariu, Alin Constantin
Faur, Flaviu Ionut
Nemteanu, Roxana
Cozma, Tudor Cristian
Scripcariu, Dragoș Viorel
Floria, Mariana
Clim, Andreea
Serban, Dragomir Nicolae
Maranduca, Minela Aida
Author_xml – sequence: 1
  givenname: Andreea
  surname: Clim
  fullname: Clim, Andreea
– sequence: 2
  givenname: Minela Aida
  orcidid: 0000-0002-2736-9700
  surname: Maranduca
  fullname: Maranduca, Minela Aida
– sequence: 3
  givenname: Nina
  orcidid: 0000-0003-0949-7538
  surname: Filip
  fullname: Filip, Nina
– sequence: 4
  givenname: Daniela Maria
  orcidid: 0000-0002-7144-2506
  surname: Tănase
  fullname: Tănase, Daniela Maria
– sequence: 5
  givenname: Mariana
  orcidid: 0000-0002-9465-1503
  surname: Floria
  fullname: Floria, Mariana
– sequence: 6
  givenname: Alin Constantin
  orcidid: 0000-0001-5730-1662
  surname: Pinzariu
  fullname: Pinzariu, Alin Constantin
– sequence: 7
  givenname: Irene Paula
  surname: Popa
  fullname: Popa, Irene Paula
– sequence: 8
  givenname: Roxana
  surname: Nemteanu
  fullname: Nemteanu, Roxana
– sequence: 9
  givenname: Tudor Cristian
  orcidid: 0000-0001-7825-7832
  surname: Cozma
  fullname: Cozma, Tudor Cristian
– sequence: 10
  givenname: Flaviu Ionut
  surname: Faur
  fullname: Faur, Flaviu Ionut
– sequence: 11
  givenname: Dragomir Nicolae
  surname: Serban
  fullname: Serban, Dragomir Nicolae
– sequence: 12
  givenname: Dragoș Viorel
  surname: Scripcariu
  fullname: Scripcariu, Dragoș Viorel
– sequence: 13
  givenname: Ionela Lacramioara
  surname: Serban
  fullname: Serban, Ionela Lacramioara
BookMark eNpNkM9KAzEQxoMoWGtvPkAewNWk2d1sjqVWW2gp6N6X_JlgZJuUTSzt0Tc3RQ8dGGYuv2---e7QtQ8eEHqg5IkxQZ57Z4GWlOYur9BoSnhVUD4V1xf7LZrE-EVy1RWtm3KEftpPwCtv-2_wGnCweJbCcJAxyeQ8bgeQaQc-4eDxMuyCPsUEzgPeQJIq9C7usPQGb4_OZOIA-CMNECPOsPR4cdzD4M4CssebYKA_n3hxUkFyGr_LFO_RjZV9hMn_HKP2ddHOl8V6-7aaz9aF5lVZSFqLpmTCcGKJEpbVijSVMmCF5oqD4lLVU5N_1IJJ1ZCaMG21ISozJJNj9Pgnq4cQ4wC222djcjh1lHTnALvLANkvmTNn1g
Cites_doi 10.1016/j.molonc.2011.11.003
10.12997/jla.2020.9.1.162
10.1007/s00404-014-3295-4
10.1016/S0021-9150(00)00474-3
10.5114/aoms.2017.69494
10.21608/ejhm.2007.17696
10.1111/1755-5922.12002
10.1056/NEJMoa043545
10.3892/etm.2016.3794
10.1371/journal.pone.0259072
10.3390/ijms20040867
10.1093/ajcn/72.2.315
10.1007/s11010-017-3099-5
10.2174/0929867330666230413090416
10.4061/2010/253803
10.1016/j.crphar.2022.100088
10.1016/j.jchromb.2013.09.010
10.1007/s00018-022-04286-2
10.1016/j.bbrc.2005.03.204
10.3389/fphar.2019.01568
10.1186/s12933-023-01965-7
10.1080/14779072.2018.1497974
10.1016/j.bbrc.2004.04.021
10.1016/j.phrs.2005.05.004
10.2147/DDDT.S112241
10.2147/DDDT.S379335
10.1055/a-1952-1946
10.1139/cjpp-2012-0325
10.1016/S0008-6363(01)00382-0
10.1056/NEJMoa040583
10.1016/S0021-9150(00)00735-8
10.1093/jn/130.2.369S
10.1016/S0039-9140(99)00235-0
10.1254/fpj.117.65
10.1161/STROKEAHA.107.493106
10.47631/jsrmbs.v2i3.297
10.1016/S0140-6736(03)12948-0
10.1001/jama.285.13.1711
10.1016/j.jdiacomp.2020.107767
10.1177/0091270003255920
10.1093/eurheartj/ehm565
10.3389/fcvm.2022.898305
10.3390/jcm9061995
10.1016/j.amjcard.2020.09.043
10.2478/acph-2024-0001
10.1016/S0002-8703(02)00142-4
10.1111/joim.13279
10.1016/j.nut.2011.04.009
10.3892/mmr.2016.4975
10.2174/0929867323666161007155310
10.1016/S0140-6736(13)61752-3
10.3389/fcvm.2022.1023651
10.1016/j.jacc.2013.11.002
10.4103/njcp.njcp_345_17
10.1038/aps.2010.22
10.1007/s00228-006-0176-1
10.1161/hq0202.104081
10.1177/1076029620920369
10.1016/S1995-7645(14)60064-X
10.1056/NEJMoa050461
10.1016/j.transproceed.2015.09.035
10.1186/s12944-021-01524-7
10.1161/01.CIR.0000080895.05158.8B
10.1161/CIR.0b013e3182160726
10.1515/cclm-2012-0694
10.1097/FJC.0b013e318167141f
10.1016/j.ejim.2010.12.003
10.1016/j.febslet.2009.03.038
10.21037/jtd-22-78
10.3390/nu14071412
10.1186/s12872-022-02525-9
10.3390/antiox13080923
10.1007/s00431-005-0033-8
10.1038/s41467-020-19197-8
ContentType Journal Article
DBID AAYXX
CITATION
DOI 10.3390/life14111414
DatabaseName CrossRef
DatabaseTitle CrossRef
DatabaseTitleList CrossRef
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2075-1729
ExternalDocumentID 10_3390_life14111414
GroupedDBID 53G
5VS
7XC
8FE
8FH
AADQD
AAFWJ
AAYXX
ABDBF
ADBBV
AFKRA
AFPKN
AFZYC
ALMA_UNASSIGNED_HOLDINGS
AOIJS
ATCPS
BAWUL
BBNVY
BCNDV
BENPR
BHPHI
CCPQU
CITATION
DIK
ESX
GROUPED_DOAJ
HCIFZ
HYE
IAO
ISR
ITC
KQ8
LK8
M7P
MODMG
M~E
OK1
PATMY
PGMZT
PIMPY
PROAC
PYCSY
RIG
RPM
ID FETCH-LOGICAL-c754-a1698439d70f0b9f36b085bdef9c7b7eb7ab62d729c93ab80603cfcd0b39d0843
ISSN 2075-1729
IngestDate Wed Nov 06 13:25:17 EST 2024
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 11
Language English
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c754-a1698439d70f0b9f36b085bdef9c7b7eb7ab62d729c93ab80603cfcd0b39d0843
ORCID 0000-0002-9465-1503
0000-0002-2736-9700
0000-0003-0949-7538
0000-0002-7144-2506
0000-0001-7825-7832
0000-0001-5730-1662
OpenAccessLink https://doi.org/10.3390/life14111414
ParticipantIDs crossref_primary_10_3390_life14111414
PublicationCentury 2000
PublicationDate 2024-11-02
PublicationDateYYYYMMDD 2024-11-02
PublicationDate_xml – month: 11
  year: 2024
  text: 2024-11-02
  day: 02
PublicationDecade 2020
PublicationTitle Life (Basel, Switzerland)
PublicationYear 2024
References Smith (ref_16) 2013; 51
Simsek (ref_31) 2014; 290
Cannon (ref_58) 2004; 350
Shishehbor (ref_86) 2003; 108
Chrysant (ref_21) 2018; 16
Gocmen (ref_44) 2013; 91
Makhlouf (ref_38) 2021; 2
Wassmann (ref_78) 2002; 22
Moon (ref_81) 2020; 9
Sadeghi (ref_52) 2014; 10
Amin (ref_33) 2009; 2
Kaya (ref_36) 2024; 74
Ingenbleek (ref_14) 2012; 28
Gopu (ref_15) 2013; 939
ref_18
Erkocoglu (ref_13) 2013; 55
ref_17
Kumar (ref_87) 2005; 331
Giral (ref_67) 2001; 154
Cangemi (ref_76) 2008; 29
Melenovsky (ref_71) 2002; 144
McDowell (ref_7) 2000; 130
Patel (ref_61) 2010; 11
Chen (ref_77) 2012; 6
Brattstrom (ref_8) 2000; 72
Habib (ref_2) 2023; 27
ref_25
ref_23
Wang (ref_5) 2022; 14
Qiu (ref_29) 2008; 51
Fogari (ref_63) 2006; 62
An (ref_24) 2023; 22
Wanner (ref_59) 2005; 353
Sahebkar (ref_39) 2016; 23
ref_28
Bhandari (ref_62) 2011; 49
ref_27
Nikolic (ref_80) 2018; 437
Cusumano (ref_79) 2015; 47
Wong (ref_40) 2021; 137
Jiang (ref_65) 2013; 31
Dundar (ref_12) 2018; 4
Jia (ref_69) 2016; 13
Llaverias (ref_30) 2004; 318
Wang (ref_9) 2021; 20
Lee (ref_85) 2017; 11
Amarenco (ref_54) 2007; 38
Stone (ref_82) 2014; 63
Mahmood (ref_1) 2014; 383
Sigit (ref_66) 2001; 155
Akbari (ref_72) 2024; 31
Celik (ref_11) 2018; 21
Wu (ref_64) 2020; 26
Bao (ref_32) 2010; 31
Schwartz (ref_57) 2001; 285
Zheng (ref_45) 2018; 14
Xu (ref_47) 2014; 7
LaRosa (ref_56) 2005; 352
MacMahon (ref_70) 2000; 10
Srinivasan (ref_48) 2005; 52
Zhu (ref_10) 2006; 165
Smith (ref_20) 2021; 290
Li (ref_46) 2022; 16
Malik (ref_68) 2001; 52
Nazar (ref_42) 2021; 17
Funatsu (ref_53) 2001; 117
Milionis (ref_35) 2003; 43
Liu (ref_26) 2022; 79
Bald (ref_43) 2000; 50
Miller (ref_51) 2011; 123
Zhang (ref_19) 2020; 11
Bloom (ref_75) 2010; 2010
ref_84
Alkaissi (ref_6) 2023; 15
ref_3
Koksal (ref_74) 2011; 22
Virani (ref_83) 2023; 82
Gueant (ref_22) 2023; 123
(ref_34) 2007; 29
Obeid (ref_60) 2009; 583
Ghasemi (ref_50) 2023; 22
Verma (ref_37) 2022; 3
Herbet (ref_73) 2016; 12
ref_4
Sever (ref_55) 2003; 361
Wang (ref_49) 2011; 40
Zhao (ref_41) 2021; 35
References_xml – volume: 6
  start-page: 62
  year: 2012
  ident: ref_77
  article-title: Atorvastatin Reduces Vascular Endothelial Growth Factor (VEGF) Expression in Human Non-Small Cell Lung Carcinomas (NSCLCs) via Inhibition of Reactive Oxygen Species (ROS) Production
  publication-title: Mol. Oncol.
  doi: 10.1016/j.molonc.2011.11.003
  contributor:
    fullname: Chen
– volume: 9
  start-page: 162
  year: 2020
  ident: ref_81
  article-title: Efficacy and Safety of High-Dose Atorvastatin in Moderate-to-High Cardiovascular Risk Postmenopausal Korean Women with Dyslipidemia
  publication-title: J. Lipid Atheroscler.
  doi: 10.12997/jla.2020.9.1.162
  contributor:
    fullname: Moon
– volume: 290
  start-page: 999
  year: 2014
  ident: ref_31
  article-title: Atorvastatin Exerts Anti-Nociceptive Activity and Decreases Serum Levels of High-Sensitivity C-Reactive Protein and Tumor Necrosis Factor-α in a Rat Endometriosis Model
  publication-title: Arch. Gynecol. Obstet.
  doi: 10.1007/s00404-014-3295-4
  contributor:
    fullname: Simsek
– volume: 2
  start-page: 254
  year: 2009
  ident: ref_33
  article-title: Oxidative Markers, Nitric Oxide and Homocysteine Alteration in Hypercholesterolimic Rats: Role of Atorvastatine and Cinnamon
  publication-title: Int. J. Clin. Exp. Med.
  contributor:
    fullname: Amin
– volume: 154
  start-page: 421
  year: 2001
  ident: ref_67
  article-title: Homocysteine and Lipid Lowering Agents. A Comparison between Atorvastatin and Fenofibrate in Patients with Mixed Hyperlipidemia
  publication-title: Atherosclerosis
  doi: 10.1016/S0021-9150(00)00474-3
  contributor:
    fullname: Giral
– volume: 14
  start-page: 629
  year: 2018
  ident: ref_45
  article-title: Effects and Potential Mechanism of Atorvastatin Treatment on Lp-PLA2 in Rats with Dyslipidemia
  publication-title: Aoms
  doi: 10.5114/aoms.2017.69494
  contributor:
    fullname: Zheng
– volume: 29
  start-page: 511
  year: 2007
  ident: ref_34
  article-title: Efficacy of Oat Bran (Avena sativa L.) in Comparison with Atorvastatin in Treatment of Hypercholesterolemia in Albino Rat Liver
  publication-title: Egypt. J. Hosp. Med.
  doi: 10.21608/ejhm.2007.17696
– volume: 31
  start-page: e27
  year: 2013
  ident: ref_65
  article-title: Effect of Simvastatin on Plasma Homocysteine Levels and Its Modification by MTHFR C677T Polymorphism in Chinese Patients with Primary Hyperlipidemia
  publication-title: Cardiovasc. Ther.
  doi: 10.1111/1755-5922.12002
  contributor:
    fullname: Jiang
– volume: 353
  start-page: 238
  year: 2005
  ident: ref_59
  article-title: German Diabetes and Dialysis Study Investigators. Atorvastatin in Patients with Type 2 Diabetes Mellitus Undergoing Hemodialysis
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa043545
  contributor:
    fullname: Wanner
– volume: 12
  start-page: 3440
  year: 2016
  ident: ref_73
  article-title: Effect of the Interaction between Atorvastatin and Selective Serotonin Reuptake Inhibitors on the Blood Redox Equilibrium
  publication-title: Exp. Ther. Med.
  doi: 10.3892/etm.2016.3794
  contributor:
    fullname: Herbet
– ident: ref_84
  doi: 10.1371/journal.pone.0259072
– ident: ref_17
  doi: 10.3390/ijms20040867
– volume: 72
  start-page: 315
  year: 2000
  ident: ref_8
  article-title: Homocysteine and cardiovascular disease: Cause or effect?
  publication-title: Am. J. Clin. Nutr.
  doi: 10.1093/ajcn/72.2.315
  contributor:
    fullname: Brattstrom
– volume: 437
  start-page: 109
  year: 2018
  ident: ref_80
  article-title: Effects of Atorvastatin and Simvastatin on Oxidative Stress in Diet-Induced Hyperhomocysteinemia in Wistar Albino Rats: A Comparative Study
  publication-title: Mol. Cell. Biochem.
  doi: 10.1007/s11010-017-3099-5
  contributor:
    fullname: Nikolic
– volume: 31
  start-page: 1920
  year: 2024
  ident: ref_72
  article-title: Impact of Statin or Fibrate Therapy on Homocysteine Concentrations: A Systematic Review and Meta-analysis
  publication-title: Curr. Med. Chem.
  doi: 10.2174/0929867330666230413090416
  contributor:
    fullname: Akbari
– volume: 2010
  start-page: 253803
  year: 2010
  ident: ref_75
  article-title: Statins Decrease Oxidative Stress and ICD Therapies
  publication-title: Cardiol. Res. Pract.
  doi: 10.4061/2010/253803
  contributor:
    fullname: Bloom
– volume: 3
  start-page: 100088
  year: 2022
  ident: ref_37
  article-title: Simvastatin Ameliorates Oxidative Stress Levels in HepG2 Cells and Hyperlipidemic Rats
  publication-title: Curr. Res. Pharmacol. Drug Discov.
  doi: 10.1016/j.crphar.2022.100088
  contributor:
    fullname: Verma
– volume: 939
  start-page: 32
  year: 2013
  ident: ref_15
  article-title: Simultaneous determination of homocysteine and asymmetric dimethylarginine in human urine by liquid chromatography-tandem mass spectrometry
  publication-title: J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
  doi: 10.1016/j.jchromb.2013.09.010
  contributor:
    fullname: Gopu
– volume: 79
  start-page: 272
  year: 2022
  ident: ref_26
  article-title: Adipokines, adiposity, and atherosclerosis
  publication-title: Cell. Mol. Life Sci.
  doi: 10.1007/s00018-022-04286-2
  contributor:
    fullname: Liu
– volume: 331
  start-page: 442
  year: 2005
  ident: ref_87
  article-title: Statins Downregulate Myeloperoxidase Gene Expression in Macrophages
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2005.03.204
  contributor:
    fullname: Kumar
– ident: ref_27
  doi: 10.3389/fphar.2019.01568
– volume: 22
  start-page: 237
  year: 2023
  ident: ref_24
  article-title: The Role of Oxidative Stress in Diabetes Mellitus-Induced Vascular Endothelial Dysfunction
  publication-title: Cardiovasc. Diabetol.
  doi: 10.1186/s12933-023-01965-7
  contributor:
    fullname: An
– volume: 16
  start-page: 559
  year: 2018
  ident: ref_21
  article-title: The current status of homocysteine as a risk factor for cardiovascular disease: A mini review
  publication-title: Expert. Rev. Cardiovasc. Ther.
  doi: 10.1080/14779072.2018.1497974
  contributor:
    fullname: Chrysant
– volume: 318
  start-page: 265
  year: 2004
  ident: ref_30
  article-title: Atorvastatin Reduces CD68, FABP4, and HBP Expression in OxLDL-Treated Human Macrophages
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2004.04.021
  contributor:
    fullname: Llaverias
– volume: 52
  start-page: 313
  year: 2005
  ident: ref_48
  article-title: Combination of High-Fat Diet-Fed and Low-Dose Strepto-zotocin-Treated Rat: A Model for Type 2 Diabetes and Pharmacological Screening
  publication-title: Pharmacol. Res.
  doi: 10.1016/j.phrs.2005.05.004
  contributor:
    fullname: Srinivasan
– volume: 11
  start-page: 2277
  year: 2017
  ident: ref_85
  article-title: Efficacy and Tolerability of Two Different Formulations of Atorvastatin in Korean Patients with Hypercholesterolemia: A Multicenter, Prospective, Randomized Clinical Trial
  publication-title: DDDT
  doi: 10.2147/DDDT.S112241
  contributor:
    fullname: Lee
– volume: 16
  start-page: 3805
  year: 2022
  ident: ref_46
  article-title: Atorvastatin Inhibits High-Fat Diet-Induced Lipid Metabolism Disorders in Rats by Inhibiting Bacteroides Reduction and Improving Metabolism
  publication-title: DDDT
  doi: 10.2147/DDDT.S379335
  contributor:
    fullname: Li
– volume: 123
  start-page: 270
  year: 2023
  ident: ref_22
  article-title: Hyperhomocysteinemia in Cardiovascular Diseases: Revisiting Observational Studies and Clinical Trials
  publication-title: Thromb. Haemost.
  doi: 10.1055/a-1952-1946
  contributor:
    fullname: Gueant
– volume: 91
  start-page: 680
  year: 2013
  ident: ref_44
  article-title: Effect of Atorvastatin on Atherosclerotic Plaque Formation and Platelet Activation in Hypercholesterolemic Rats
  publication-title: Can. J. Physiol. Pharmacol.
  doi: 10.1139/cjpp-2012-0325
  contributor:
    fullname: Gocmen
– volume: 52
  start-page: 290
  year: 2001
  ident: ref_68
  article-title: Both Fenofibrate and Atorvastatin Improve Vascular Reactivity in Combined Hyperlipidaemia (Fenofibrate versus Atorvastatin Trial–FAT)
  publication-title: Cardiovasc. Res.
  doi: 10.1016/S0008-6363(01)00382-0
  contributor:
    fullname: Malik
– volume: 350
  start-page: 1495
  year: 2004
  ident: ref_58
  article-title: Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 Investigators. Intensive versus Moderate Lipid Lowering with Statins after Acute Coronary Syndromes
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa040583
  contributor:
    fullname: Cannon
– volume: 155
  start-page: 265
  year: 2001
  ident: ref_66
  article-title: High-Dose Simvastin (80 Mg/Day) Decreases Plasma Concentrations of Total Homocyst(e)Ine in Patients with Hypercholesteromia
  publication-title: Atherosclerosis
  doi: 10.1016/S0021-9150(00)00735-8
  contributor:
    fullname: Sigit
– volume: 130
  start-page: 369S
  year: 2000
  ident: ref_7
  article-title: Homocysteine and endothelial dysfunction: A link with cardiovascular disease
  publication-title: J. Nutr.
  doi: 10.1093/jn/130.2.369S
  contributor:
    fullname: McDowell
– volume: 82
  start-page: 833
  year: 2023
  ident: ref_83
  article-title: 2023 Aha/Acc/Accp/Aspc/Nla/Pcna Guideline for the Management of Patients with Chronic Coronary Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines
  publication-title: Circulation
  contributor:
    fullname: Virani
– volume: 11
  start-page: 819
  year: 2010
  ident: ref_61
  article-title: Effects of Atorvastatin as Antioxidants in Diabetic Associated Cardiovascular Complications
  publication-title: J. Pharm. Sci. Res.
  contributor:
    fullname: Patel
– volume: 50
  start-page: 1233
  year: 2000
  ident: ref_43
  article-title: Liquid Chromatographic Assessment of Total and Protein-Bound Homocysteine in Human Plasma
  publication-title: Talanta
  doi: 10.1016/S0039-9140(99)00235-0
  contributor:
    fullname: Bald
– volume: 117
  start-page: 65
  year: 2001
  ident: ref_53
  article-title: Atorvastatin (Lipitor): A review of its pharmacological and clinical profile
  publication-title: Nihon Yakurigaku Zasshi
  doi: 10.1254/fpj.117.65
  contributor:
    fullname: Funatsu
– volume: 38
  start-page: 3198
  year: 2007
  ident: ref_54
  article-title: Effects of Intense Low-Density Lipoprotein Cholesterol Reduction in Patients with Stroke or Transient Ischemic Attack: The Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Trial
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.107.493106
  contributor:
    fullname: Amarenco
– volume: 2
  start-page: 39
  year: 2021
  ident: ref_38
  article-title: Effects of Vitamin D and Simvastatin on Inflammatory and Oxidative Stress Markers of High-Fat Diet-Induced Obese Rats
  publication-title: JSRMBS
  doi: 10.47631/jsrmbs.v2i3.297
  contributor:
    fullname: Makhlouf
– volume: 361
  start-page: 1149
  year: 2003
  ident: ref_55
  article-title: Prevention of Coronary and Stroke Events with Atorvastatin in Hypertensive Patients Who Have Average or Lower-than-Average Cholesterol Concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA): A Multicentre Randomised Controlled Trial
  publication-title: Lancet
  doi: 10.1016/S0140-6736(03)12948-0
  contributor:
    fullname: Sever
– volume: 285
  start-page: 1711
  year: 2001
  ident: ref_57
  article-title: Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) Study Investigators. Effects of Atorvastatin on Early Recurrent Ischemic Events in Acute Coronary Syndromes: The MIRACL Study: A Randomized Controlled Trial
  publication-title: JAMA
  doi: 10.1001/jama.285.13.1711
  contributor:
    fullname: Schwartz
– volume: 35
  start-page: 107767
  year: 2021
  ident: ref_41
  article-title: Diabetes associated residual atherosclerotic cardiovascular risk in statin-treated patients with prior atherosclerotic cardiovascular disease
  publication-title: J. Diabetes Complicat.
  doi: 10.1016/j.jdiacomp.2020.107767
  contributor:
    fullname: Zhao
– volume: 43
  start-page: 825
  year: 2003
  ident: ref_35
  article-title: Comparative Effects of Atorvastatin, Simvastatin, and Fenofibrate on Serum Homocysteine Levels in Patients with Primary Hyperlipidemia
  publication-title: J. Clin. Pharmacol.
  doi: 10.1177/0091270003255920
  contributor:
    fullname: Milionis
– volume: 29
  start-page: 54
  year: 2008
  ident: ref_76
  article-title: Early Decrease of Oxidative Stress by Atorvastatin in Hypercholesterolaemic Patients: Effect on Circulating Vitamin E
  publication-title: Eur. Heart J.
  doi: 10.1093/eurheartj/ehm565
  contributor:
    fullname: Cangemi
– volume: 49
  start-page: 132
  year: 2011
  ident: ref_62
  article-title: Ameliorative Role of Atorvastatin on Methionine-Induced Hyperhomocysteinemia and Hematological Changes in Albino Rats
  publication-title: Indian J. Exp. Biol.
  contributor:
    fullname: Bhandari
– volume: 15
  start-page: e42259
  year: 2023
  ident: ref_6
  article-title: Hyperhomocysteinemia and Accelerated Aging: The Pathogenic Role of Increased Homocysteine in Atherosclerosis, Osteoporosis, and Neurodegeneration
  publication-title: Cureus
  contributor:
    fullname: Alkaissi
– ident: ref_18
  doi: 10.3389/fcvm.2022.898305
– ident: ref_25
  doi: 10.3390/jcm9061995
– volume: 137
  start-page: 7
  year: 2021
  ident: ref_40
  article-title: Five-Year Residual Atherosclerotic Cardiovascular Disease Risk Prediction Model for Statin Treated Patients with Known Cardiovascular Disease
  publication-title: Am. J. Cardiol.
  doi: 10.1016/j.amjcard.2020.09.043
  contributor:
    fullname: Wong
– volume: 74
  start-page: 117
  year: 2024
  ident: ref_36
  article-title: Comparative effects of pravastatin and rosuvastatin on carbohydrate metabolism in an experimental diabetic rat model
  publication-title: Acta Pharm.
  doi: 10.2478/acph-2024-0001
  contributor:
    fullname: Kaya
– volume: 144
  start-page: E6
  year: 2002
  ident: ref_71
  article-title: Comparison of the Effects of Atorvastatin or Fenofibrate on Nonlipid Biochemical Risk Factors and the LDL Particle Size in Subjects with Combined Hyperlipidemia
  publication-title: Am. Heart J.
  doi: 10.1016/S0002-8703(02)00142-4
  contributor:
    fullname: Melenovsky
– volume: 55
  start-page: 510
  year: 2013
  ident: ref_13
  article-title: Carotid intima media thickness in adolescents with increased risk for atherosclerosis
  publication-title: Turk. J. Pediatr.
  contributor:
    fullname: Erkocoglu
– volume: 290
  start-page: 826
  year: 2021
  ident: ref_20
  article-title: Homocysteine—From disease biomarker to disease prevention
  publication-title: J. Int. Med.
  doi: 10.1111/joim.13279
  contributor:
    fullname: Smith
– volume: 28
  start-page: 148
  year: 2012
  ident: ref_14
  article-title: Vegetarianism produces subclinical malnutrition, hyperhomocysteinemia and atherogenesis
  publication-title: Nutrition
  doi: 10.1016/j.nut.2011.04.009
  contributor:
    fullname: Ingenbleek
– volume: 13
  start-page: 3574
  year: 2016
  ident: ref_69
  article-title: Atorvastatin Attenuates Atherosclerotic Plaque Destabilization by Inhibiting Endoplasmic Reticulum Stress in Hyperhomocysteinemic Mice
  publication-title: Mol. Med. Rep.
  doi: 10.3892/mmr.2016.4975
  contributor:
    fullname: Jia
– volume: 23
  start-page: 4490
  year: 2016
  ident: ref_39
  article-title: A Systematic Review and Meta-Analysis of Controlled Trials on the Effects of Statin and Fibrate Therapies on Plasma Homocysteine Levels
  publication-title: Curr. Med. Chem.
  doi: 10.2174/0929867323666161007155310
  contributor:
    fullname: Sahebkar
– volume: 383
  start-page: 999
  year: 2014
  ident: ref_1
  article-title: The Framingham Heart Study and the Epidemiology of Cardiovascular Disease: A Historical Perspective
  publication-title: Lancet
  doi: 10.1016/S0140-6736(13)61752-3
  contributor:
    fullname: Mahmood
– volume: 17
  start-page: 162
  year: 2021
  ident: ref_42
  article-title: Effect of High-Fat Diet on SOD2, GPx, NeuN and BDNF Expression on Frontal Lobe of Obese Rats
  publication-title: Mal. J. Med. Health Sci.
  contributor:
    fullname: Nazar
– ident: ref_4
  doi: 10.3389/fcvm.2022.1023651
– volume: 63
  start-page: 2889
  year: 2014
  ident: ref_82
  article-title: 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults
  publication-title: J. Am. Coll. Cardiol.
  doi: 10.1016/j.jacc.2013.11.002
  contributor:
    fullname: Stone
– volume: 21
  start-page: 1012
  year: 2018
  ident: ref_11
  article-title: Subclinical atherosclerosis and impaired cardiac autonomic control in pediatric patients with Vitamin B12 deficiency
  publication-title: Niger. J. Clin. Pract.
  doi: 10.4103/njcp.njcp_345_17
  contributor:
    fullname: Celik
– volume: 31
  start-page: 476
  year: 2010
  ident: ref_32
  article-title: Atorvastatin Inhibits Homocysteine-Induced Dysfunction and Apoptosis in Endothelial Progenitor Cells
  publication-title: Acta Pharmacol. Sin.
  doi: 10.1038/aps.2010.22
  contributor:
    fullname: Bao
– volume: 40
  start-page: 99
  year: 2011
  ident: ref_49
  article-title: Effect of the duration of high-fat diet and the dosage of streptozotocin on establish-ing experimental animal model of type 2 diabetes mellitus
  publication-title: Wei Sheng Yan Jiu
  contributor:
    fullname: Wang
– volume: 62
  start-page: 817
  year: 2006
  ident: ref_63
  article-title: Effects of Amlodipine-Atorvastatin Combination on Inflammation Markers and Insulin Sensitivity in Normocholesterolemic Obese Hypertensive Patients
  publication-title: Eur. J. Clin. Pharmacol.
  doi: 10.1007/s00228-006-0176-1
  contributor:
    fullname: Fogari
– volume: 22
  start-page: 300
  year: 2002
  ident: ref_78
  article-title: Cellular Antioxidant Effects of Atorvastatin in Vitro and in Vivo
  publication-title: Arterioscler. Thromb. Vasc. Biol.
  doi: 10.1161/hq0202.104081
  contributor:
    fullname: Wassmann
– volume: 26
  start-page: 1076029620920369
  year: 2020
  ident: ref_64
  article-title: Changes in Homocysteine Levels Affect Serum Lipid Response to Atorvastatin in Patients With Acute Coronary Syndrome: A Retrospective Observational Study
  publication-title: Clin. Appl. Thromb. Hemost.
  doi: 10.1177/1076029620920369
  contributor:
    fullname: Wu
– volume: 7
  start-page: 398
  year: 2014
  ident: ref_47
  article-title: Effect of Atorvastatin on Serum Oxidative Stress and N-Terminal Brain Natriuretic Peptide Expression in Rats
  publication-title: Asian Pac. J. Trop. Med.
  doi: 10.1016/S1995-7645(14)60064-X
  contributor:
    fullname: Xu
– volume: 352
  start-page: 1425
  year: 2005
  ident: ref_56
  article-title: Treating to New Targets (TNT) Investigators. Intensive Lipid Lowering with Atorvastatin in Patients with Stable Coronary Disease
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa050461
  contributor:
    fullname: LaRosa
– volume: 10
  start-page: 195
  year: 2000
  ident: ref_70
  article-title: A Pilot Study with Simvastatin and Folic Acid/Vitamin B12 in Preparation for the Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine (SEARCH)
  publication-title: Nutr. Metab. Cardiovasc. Dis.
  contributor:
    fullname: MacMahon
– volume: 47
  start-page: 2757
  year: 2015
  ident: ref_79
  article-title: N-Acetylcysteine and High-Dose Atorvastatin Reduce Oxidative Stress in an Ischemia-Reperfusion Model in the Rat Kidney
  publication-title: Transplant. Proc.
  doi: 10.1016/j.transproceed.2015.09.035
  contributor:
    fullname: Cusumano
– volume: 27
  start-page: 8598
  year: 2023
  ident: ref_2
  article-title: Homocysteine as a predictor and prognostic marker of atherosclerotic cardiovascular disease: A systematic review and meta-analysis
  publication-title: Eur. Rev. Med. Pharmacol. Sci.
  contributor:
    fullname: Habib
– volume: 20
  start-page: 108
  year: 2021
  ident: ref_9
  article-title: Effects of chemerin and homocysteine levels and their associations with occurrence and development of ischemic cerebrovascular disease
  publication-title: Lipids Health Dis.
  doi: 10.1186/s12944-021-01524-7
  contributor:
    fullname: Wang
– volume: 10
  start-page: 298
  year: 2014
  ident: ref_52
  article-title: The Effects of Different Doses of Atorvastatin on Serum Lipid Profile, Glycemic Control, and Liver Enzymes in Patients with Ischemic Cerebrovascular Accident
  publication-title: ARYA Atheroscler.
  contributor:
    fullname: Sadeghi
– volume: 108
  start-page: 426
  year: 2003
  ident: ref_86
  article-title: Statins Promote Potent Systemic Antioxidant Effects through Specific Inflammatory Pathways
  publication-title: Circulation
  doi: 10.1161/01.CIR.0000080895.05158.8B
  contributor:
    fullname: Shishehbor
– volume: 123
  start-page: 2292
  year: 2011
  ident: ref_51
  article-title: Triglycerides and cardiovascular disease: A scientific statement from the American Heart Association
  publication-title: Circulation
  doi: 10.1161/CIR.0b013e3182160726
  contributor:
    fullname: Miller
– volume: 51
  start-page: 1643
  year: 2013
  ident: ref_16
  article-title: Folic acid supplementation does not reduce intracellular homocysteine, and may disturb intracellular one-carbon metabolism
  publication-title: Clin. Chem. Lab. Med.
  doi: 10.1515/cclm-2012-0694
  contributor:
    fullname: Smith
– volume: 51
  start-page: 388
  year: 2008
  ident: ref_29
  article-title: Atorvastatin Inhibits ABCA1 Expression and Cholesterol Efflux in THP-1 Macrophages by an LXR-Dependent Pathway
  publication-title: J. Cardiovasc. Pharmacol.
  doi: 10.1097/FJC.0b013e318167141f
  contributor:
    fullname: Qiu
– volume: 22
  start-page: 249
  year: 2011
  ident: ref_74
  article-title: The Effects of Atorvastatin and Rosuvastatin on Oxidative Stress in Diabetic Patients
  publication-title: Eur. J. Intern. Med.
  doi: 10.1016/j.ejim.2010.12.003
  contributor:
    fullname: Koksal
– volume: 22
  start-page: 274
  year: 2023
  ident: ref_50
  article-title: Streptozotocin as a Tool for Induction of Rat Models of Diabetes: A Practical Guide
  publication-title: EXCLI J.
  contributor:
    fullname: Ghasemi
– volume: 583
  start-page: 1215
  year: 2009
  ident: ref_60
  article-title: Homocysteine and Lipids: S-Adenosyl Methionine as a Key Intermediate
  publication-title: FEBS Lett.
  doi: 10.1016/j.febslet.2009.03.038
  contributor:
    fullname: Obeid
– volume: 14
  start-page: 646
  year: 2022
  ident: ref_5
  article-title: Systematic Review and Meta-Analysis of the Correlation between Plasma Homocysteine Levels and Coronary Heart Disease
  publication-title: J. Thorac. Dis.
  doi: 10.21037/jtd-22-78
  contributor:
    fullname: Wang
– ident: ref_23
  doi: 10.3390/nu14071412
– ident: ref_28
  doi: 10.1186/s12872-022-02525-9
– ident: ref_3
  doi: 10.3390/antiox13080923
– volume: 4
  start-page: 1
  year: 2018
  ident: ref_12
  article-title: The Relation between circulating endothelial microparticles and carotid intima media thickness in Vitamin B12 deficient adolescents
  publication-title: J. Integr. Cardiol.
  contributor:
    fullname: Dundar
– volume: 165
  start-page: 326
  year: 2006
  ident: ref_10
  article-title: Elevated plasma homocysteine in obese schoolchildren with early atherosclerosis
  publication-title: Eur. J. Pediatr.
  doi: 10.1007/s00431-005-0033-8
  contributor:
    fullname: Zhu
– volume: 11
  start-page: 5426
  year: 2020
  ident: ref_19
  article-title: Modeling early stage atherosclerosis in a primary human vascular microphysiological system
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-19197-8
  contributor:
    fullname: Zhang
SSID ssj0000651684
Score 2.354782
Snippet Objective: In our experimental study, we evaluated the influence of treatment with atorvastatin on the antioxidant activity of intracellular and extracellular...
SourceID crossref
SourceType Aggregation Database
StartPage 1414
Title The Influence of Atorvastatin Treatment on Homocysteine Metabolism and Oxidative Stress in an Experimental Model of Diabetic Rats
Volume 14
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEBbbhEIvpU_6DDq0p-DWD9leHZOQsC1sWhoXclskWQLDRi7F6SO3_qj-v440tlYNe0h7MYtWozWaD-mb2XkQ8orpUuVlYRLGM5WwuYRzkLu_C8sCyEPNBcbmLE-rxWf2_rw8n81-R1FLl4N8o6625pX8j1ZhDPTqsmT_QbNhURiAz6BfeIKG4XljHb-buox4TgkW9DfhkoQ6u9-EGHLQ8KK_6JWr2uxY5VIPoPv11B_jw4-uxfrfZ5g50rkI5bEK8lj83_VM87QVQ2hc-L3AIlAhm7oznq8ewr3o_cpn37vhCpOJI3_D0Rr7N_tISh0uhaWAS9MFm2Asv9VrsX_QbdwFJ87vg9C1YbDxVLiwArtDYrq8cPlHnYjdGTnzeX2RhzMHDpMAq8LX0lvGpmObxfDMokM4Y_jd9duhKLgLp1zDdsCUbJr2dxHua5djCFkEY8nJr2LpW2Q3h_MNDtbdw-PTj5-Ccw94XVb5btfh1THpwi3xNl4iokMRr2nukbujQUIPEF33yUzbB-Q2tij9-ZD8AozRgDHaGxpjjAaM0d7SGGN0gzEKiqUBYxQxRkFYWBpjjHqMuZ-YMEYdxh6R5uS4OVokY9uORNUlS0RW8TnQ3LZOTSq5KSoJtF622nBVy1rLWsgqb2FLFC-EnKdVWiij2lSCTAqSj8mO7a1-QigD418bCcKsZqnRnDEF9gLnhpc1U_On5PW0easvWJxltU1Pz2447zm5s4HkC7IzfL3UL4FzDnJv1PCe99n8AUZahFA
link.rule.ids 315,783,787,867,27936,27937
linkProvider ProQuest
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+Influence+of+Atorvastatin+Treatment+on+Homocysteine+Metabolism+and+Oxidative+Stress+in+an+Experimental+Model+of+Diabetic+Rats&rft.jtitle=Life+%28Basel%2C+Switzerland%29&rft.au=Clim%2C+Andreea&rft.au=Maranduca%2C+Minela+Aida&rft.au=Filip%2C+Nina&rft.au=T%C4%83nase%2C+Daniela+Maria&rft.date=2024-11-02&rft.issn=2075-1729&rft.eissn=2075-1729&rft.volume=14&rft.issue=11&rft.spage=1414&rft_id=info:doi/10.3390%2Flife14111414&rft.externalDBID=n%2Fa&rft.externalDocID=10_3390_life14111414
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2075-1729&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2075-1729&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2075-1729&client=summon