Rotavirus susceptibility of antibiotic-treated mice ascribed to diminished expression of interleukin-22

• Published in: PloS one Vol. 16; no. 8; p. e0247738
• Main Authors: Schnepf, Daniel, Hernandez, Pedro, Mahlakõiv, Tanel, Crotta, Stefania, Sullender, Meagan E., Peterson, Stefan T., Ohnemus, Annette, Michiels, Camille, Gentle, Ian, Dumoutier, Laure, Reis, Celso A., Diefenbach, Andreas, Wack, Andreas, Baldridge, Megan T., Staeheli, Peter
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 12.08.2021; Public Library of Science (PLoS)
• Subjects: Animal models; Animals; Anti-Bacterial Agents - adverse effects; Anti-Bacterial Agents - pharmacology; Antibiotics; Antiviral drugs; Apoptosis; Bacteria; Biology; Biosynthesis; Cell death; Complications and side effects; Crick, Francis; Cytokines; Development and progression; Disease Susceptibility; Female; Gastrointestinal Microbiome - drug effects; Gene Expression Profiling; Genomes; Germfree; Health aspects; Immune response; Immunology; Infections; Infectious diseases; Innate immunity; Interferon; Interleukin; Interleukin 22; Interleukins; Interleukins - metabolism; Interleukins - physiology; Intestinal Mucosa - metabolism; Intestine; Laboratories; Life Sciences; Male; Medicine; Mice; Mice, Inbred C57BL; Mice, Knockout; Microbiomes; Microbiota; Microbiota (Symbiotic organisms); Mucosal immunity; Necroptosis; Pathogens; Physiological aspects; Polysaccharides; Probiotics; Pyroptosis; Real-Time Polymerase Chain Reaction; Replication; Risk factors; Rotavirus; Rotavirus - physiology; Rotavirus infections; Rotavirus Infections - etiology; Small intestine; Stat1 protein; Supervision; Susceptibility; Viral infections; Virology; Viruses; Germany; United Kingdom > UK; Belgium; St Louis Missouri; United States > US; Portugal

The commensal microbiota regulates susceptibility to enteric pathogens by fine-tuning mucosal innate immune responses, but how susceptibility to enteric viruses is shaped by the microbiota remains incompletely understood. Past reports have indicated that commensal bacteria may either promote or repr...