Highly Pathogenic Avian Influenza Virus Subtype H5N1 in Africa: A Comprehensive Phylogenetic Analysis and Molecular Characterization of Isolates

• Published in: PloS one Vol. 4; no. 3; p. e4842
• Main Authors: Cattoli, Giovanni, Monne, Isabella, Fusaro, Alice, Joannis, Tony M, Lombin, Lami H, Aly, Mona M, Arafa, Abdel S, Sturm-Ramirez, Katharine M, Couacy-Hymann, Emmanuel, Awuni, Joseph A, Batawui, Komla B, Awoume, Kodzo A, Aplogan, Gilbert L, Sow, Adama, Ngangnou, Andre C
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 17.03.2009; Public Library of Science (PLoS)
• Subjects: Africa; Analysis; Antiviral agents; Avian flu; Avian influenza; Avian influenza viruses; Bayes Theorem; Cladistic analysis; Clustering; Drug resistance; Drugs; Epidemics; Epidemiology; Evolution; Evolution, Molecular; Evolutionary Biology/Evolutionary and Comparative Genetics; Gene sequencing; Genes; Genetics and Genomics/Comparative Genomics; Health aspects; Health risks; hemagglutinins; Infectious Diseases/Viral Infections; Influenza; Influenza A virus; Influenza A Virus, H5N1 Subtype - classification; Influenza A Virus, H5N1 Subtype - genetics; Influenza A Virus, H5N1 Subtype - pathogenicity; Laboratories; Membrane proteins; Molecular evolution; molecular sequence data; Mutation; nucleotide sequences; Outbreaks; Pandemics; pathogenicity; Phylogeny; Proteins; Public health; sialidase; strains; Virology/Emerging Viral Diseases; Viruses; Africa; Italy; Ivory Coast; Nigeria; Egypt

Highly pathogenic avian influenza virus A/H5N1 was first officially reported in Africa in early 2006. Since the first outbreak in Nigeria, this virus spread rapidly to other African countries. From its emergence to early 2008, 11 African countries experienced A/H5N1 outbreaks in poultry and human ca...