High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat

• Published in: Nature (London) Vol. 499; no. 7458; pp. 346 - 349
• Main Authors: Tian, Xiao, Azpurua, Jorge, Hine, Christopher, Vaidya, Amita, Myakishev-Rempel, Max, Ablaeva, Julia, Mao, Zhiyong, Nevo, Eviatar, Gorbunova, Vera, Seluanov, Andrei
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 18.07.2013; Nature Publishing Group
• Subjects: 631/136/7; 631/67/327; 631/67/70; 631/80/79/750; Amino Acid Sequence; Analysis; Animal tissues; Animals; Cancer; Cell Proliferation; Cell Transformation, Neoplastic - metabolism; Cells, Cultured; Colleges & universities; Contact Inhibition; Disease Resistance; Enzymes; Fibroblasts - metabolism; Glucuronosyltransferase - chemistry; Guinea Pigs; Humanities and Social Sciences; Humans; Hyaluronan Synthases; Hyaluronic acid; Hyaluronic Acid - metabolism; letter; Life span; Longevity; Mammals; Medical research; Mice; Mole Rats; Molecular Sequence Data; multidisciplinary; Naked mole-rat; Physiological aspects; Prevention; Rodents; Science; Skin; United States
• ISSN: 0028-0836; 1476-4687; 1476-4687
• DOI: 10.1038/nature12234

Naked mole rats seem almost entirely protected from developing cancer, and this can now, at least in part, be explained by the production of a unique high-molecular-mass form of hyaluronan, a component of the extracellular matrix; together with an increased sensitivity of naked mole-rat cells to hya...