Apolipoprotein E promotes subretinal mononuclear phagocyte survival and chronic inflammation in age‐related macular degeneration

• Published in: EMBO molecular medicine Vol. 7; no. 2; pp. 211 - 226
• Main Authors: Levy, Olivier, Calippe, Bertrand, Lavalette, Sophie, Hu, Shulong J, Raoul, William, Dominguez, Elisa, Housset, Michael, Paques, Michel, Sahel, José‐Alain, Bemelmans, Alexis‐Pierre, Combadiere, Christophe, Guillonneau, Xavier, Sennlaub, Florian
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.02.2015; EMBO Press; Wiley Open Access; BlackWell Publishing Ltd; Springer Nature
• Subjects: Age; age‐related macular degeneration; Alzheimer's disease; Animals; Apolipoprotein E; Apolipoproteins; Apolipoproteins E - genetics; Apolipoproteins E - immunology; CD14 antigen; Cell Survival; Cholesterol; Choroidal Neovascularization; CX3C Chemokine Receptor 1; CX3CR1 protein; EMBO19; EMBO27; Epithelium; Experiments; Fas Ligand Protein - immunology; FasL protein; Human health and pathology; Humans; Inflammation; Innate immunity; interleukin 6; Interleukin-6 - genetics; Interleukin-6 - immunology; Leukocytes (mononuclear); Life Sciences; Lipids; Macular degeneration; Macular Degeneration - genetics; Macular Degeneration - immunology; Macular Degeneration - physiopathology; Male; Mice; Mice, Knockout; mononuclear phagocyte; neuroinflammation; Neurons and Cognition; Phagocytes; Phagocytes - cytology; Phagocytes - immunology; Photoreceptors; Receptor density; Receptors, Chemokine - genetics; Receptors, Chemokine - immunology; Research Article; Retina; Retinal degeneration; Retinal pigment epithelium; Retinal Pigment Epithelium - immunology; Sensory Organs; TLR2 protein; Toll-like receptors; Transgenic animals; Vascularization; apolipoprotein E; interleukin 6; mononuclear phagocyte; age‐related macular degeneration; neuroinflammation; neuroinflammation Subject Categories Immunology; Neuroscience; age-related macular degeneration

Physiologically, the retinal pigment epithelium (RPE) expresses immunosuppressive signals such as FAS ligand (FASL), which prevents the accumulation of leukocytes in the subretinal space. Age‐related macular degeneration (AMD) is associated with a breakdown of the subretinal immunosuppressive enviro...