A comparison of the antiplatelet effects of prasugrel and high-dose clopidogrel as assessed by VASP-phosphorylation and light transmission aggregometry

• Published in: Thrombosis and haemostasis Vol. 99; no. 1; p. 215
• Main Authors: Jakubowski, Joseph A, Payne, Christopher D, Li, Ying G, Farid, Nagy A, Brandt, John T, Small, David S, Salazar, Daniel E, Winters, Kenneth J
• Format: Journal Article
• Language: English
• Published: Germany 01.01.2008
• Subjects: Adenosine Diphosphate - metabolism; Adult; Blood Platelets - drug effects; Blood Platelets - metabolism; Cell Adhesion Molecules - metabolism; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Flow Cytometry; Humans; Light; Male; Microfilament Proteins - metabolism; Middle Aged; Phosphoproteins - metabolism; Phosphorylation; Piperazines - administration & dosage; Platelet Aggregation - drug effects; Platelet Aggregation Inhibitors - administration & dosage; Platelet Function Tests - methods; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2 - metabolism; Receptors, Purinergic P2Y12; Reproducibility of Results; Thiophenes - administration & dosage; Ticlopidine - administration & dosage; Ticlopidine - analogs & derivatives; Time Factors

Platelet inhibition as measured by vasodilator-stimulated phosphoprotein (VASP) and light transmission aggregometry (LTA) have shown concordance following dosing of clopidogrel. No reports have directly compared the VASP assay and LTA at the levels of P2Y(12) blockade after loading doses (LDs) of pr...