Invasion mechanisms of Gram-positive pathogenic cocci

• Published in: Thrombosis and haemostasis Vol. 98; no. 3; p. 488
• Main Authors: Nitsche-Schmitz, D Patric, Rohde, Manfred, Chhatwal, Gursharan S
• Format: Journal Article
• Language: English
• Published: Germany 01.09.2007
• Subjects: Adhesins, Bacterial - metabolism; Animals; Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Antigens, Bacterial - metabolism; Bacterial Adhesion - drug effects; Bacterial Outer Membrane Proteins - metabolism; Bacterial Proteins - metabolism; Bacterial Translocation - drug effects; Carrier Proteins - metabolism; Caveolae - metabolism; Caveolae - microbiology; Endocytosis; Extracellular Matrix Proteins - metabolism; Humans; Hydrolases - metabolism; Phagocytes - metabolism; Phagocytes - microbiology; Phagocytosis; Staphylococcal Infections - drug therapy; Staphylococcal Infections - metabolism; Staphylococcal Infections - microbiology; Staphylococcus - drug effects; Staphylococcus - enzymology; Staphylococcus - pathogenicity; Streptococcal Infections - drug therapy; Streptococcal Infections - metabolism; Streptococcal Infections - microbiology; Streptococcus - drug effects; Streptococcus - enzymology; Streptococcus - pathogenicity

Gram-positive cocci are important human pathogens. Streptococci and staphylococci in particular are a major threat to human health, since they cause a variety of serious invasive infections. Their invasion into normally sterile sites of the host depends on elaborated bacterial mechanisms that involv...